250565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5536915..5537485 Replicon chromosome
Accession NZ_CP100443
Organism Streptomyces rimosus subsp. rimosus strain DV3

Toxin (Protein)


Gene name mazF Uniprot ID L8ERH5
Locus tag SRIMDV3_RS24080 Protein ID WP_003982453.1
Coordinates 5537138..5537485 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID L8ERT3
Locus tag SRIMDV3_RS24075 Protein ID WP_003982452.1
Coordinates 5536915..5537151 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRIMDV3_RS24060 (SRIMDV3_24165) 5532337..5533494 + 1158 WP_003982449.1 allantoicase -
SRIMDV3_RS24065 (SRIMDV3_24170) 5533566..5536142 - 2577 WP_003982450.1 aminopeptidase N -
SRIMDV3_RS24070 (SRIMDV3_24175) 5536276..5536875 + 600 WP_003982451.1 Uma2 family endonuclease -
SRIMDV3_RS24075 (SRIMDV3_24180) 5536915..5537151 + 237 WP_003982452.1 ribbon-helix-helix domain-containing protein Antitoxin
SRIMDV3_RS24080 (SRIMDV3_24185) 5537138..5537485 + 348 WP_003982453.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SRIMDV3_RS24085 (SRIMDV3_24190) 5537566..5538087 + 522 WP_003982454.1 DUF1203 domain-containing protein -
SRIMDV3_RS24090 (SRIMDV3_24195) 5538158..5539189 - 1032 WP_003982455.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12493.43 Da        Isoelectric Point: 10.8691

>T250565 WP_003982453.1 NZ_CP100443:5537138-5537485 [Streptomyces rimosus subsp. rimosus]
MRRGDLYLVDLEPVRGSEANKYRPAVVVSNDAANRSVQRAGRGVVTVVPVTANVARVYPFQVLLTADDCGLPRDSKAQCE
QVRAVSVERLGRRVGSVPARVMVGLDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8374.07 Da        Isoelectric Point: 3.7856

>AT250565 WP_003982452.1 NZ_CP100443:5536915-5537151 [Streptomyces rimosus subsp. rimosus]
MKISVSLPEEDIAFLDAYGKKTDADSRSAVIHAAVELLRASELEADYASAWEEWDESDDALLWDGVSGDGIGSADAAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8ERH5

Antitoxin

Source ID Structure
AlphaFold DB L8ERT3

References