Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1385330..1385816 Replicon chromosome
Accession NZ_CP100432
Organism Streptococcus suis T15

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NLY75_RS06960 Protein ID WP_011922754.1
Coordinates 1385330..1385599 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NLY75_RS06965 Protein ID WP_002938604.1
Coordinates 1385589..1385816 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY75_RS06935 (NLY75_06935) 1380383..1381300 - 918 WP_002937252.1 DNA-binding protein WhiA -
NLY75_RS06940 (NLY75_06940) 1381297..1382271 - 975 WP_002937257.1 YvcK family protein -
NLY75_RS06945 (NLY75_06945) 1382268..1383155 - 888 WP_011922160.1 RNase adapter RapZ -
NLY75_RS06950 (NLY75_06950) 1383177..1383554 - 378 WP_002937263.1 RidA family protein -
NLY75_RS06955 (NLY75_06955) 1383605..1384924 - 1320 WP_012775027.1 MATE family efflux transporter -
NLY75_RS06960 (NLY75_06960) 1385330..1385599 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLY75_RS06965 (NLY75_06965) 1385589..1385816 - 228 WP_002938604.1 DUF6290 family protein Antitoxin
NLY75_RS06970 (NLY75_06970) 1386088..1387434 - 1347 WP_011922752.1 asparagine--tRNA ligase -
NLY75_RS06975 (NLY75_06975) 1387449..1388630 - 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
NLY75_RS06980 (NLY75_06980) 1388627..1389124 - 498 WP_011922751.1 DUF5590 domain-containing protein -
NLY75_RS06990 (NLY75_06990) 1390324..1390773 + 450 WP_009909619.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T250557 WP_011922754.1 NZ_CP100432:c1385599-1385330 [Streptococcus suis T15]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT250557 WP_002938604.1 NZ_CP100432:c1385816-1385589 [Streptococcus suis T15]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References