Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1110085..1110577 Replicon chromosome
Accession NZ_CP100432
Organism Streptococcus suis T15

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag NLY75_RS05575 Protein ID WP_011922404.1
Coordinates 1110320..1110577 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag NLY75_RS05570 Protein ID WP_012775104.1
Coordinates 1110085..1110336 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY75_RS05550 (NLY75_05550) 1105652..1106398 + 747 WP_011922411.1 ABC transporter permease -
NLY75_RS05555 (NLY75_05555) 1106400..1107134 + 735 WP_011922410.1 ABC transporter permease -
NLY75_RS05560 (NLY75_05560) 1107270..1108022 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
NLY75_RS05565 (NLY75_05565) 1108023..1109993 + 1971 WP_023370348.1 FtsX-like permease family protein -
NLY75_RS05570 (NLY75_05570) 1110085..1110336 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
NLY75_RS05575 (NLY75_05575) 1110320..1110577 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLY75_RS05580 (NLY75_05580) 1110616..1111281 + 666 WP_012775103.1 response regulator transcription factor -
NLY75_RS05585 (NLY75_05585) 1111278..1112219 + 942 WP_023370350.1 sensor histidine kinase -
NLY75_RS05590 (NLY75_05590) 1112295..1113803 + 1509 WP_023370352.1 phosphomannomutase/phosphoglucomutase -
NLY75_RS05595 (NLY75_05595) 1113866..1114936 - 1071 WP_023370354.1 tyrosine recombinase XerS -
NLY75_RS05600 (NLY75_05600) 1115225..1115398 - 174 WP_230334484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T250556 WP_011922404.1 NZ_CP100432:1110320-1110577 [Streptococcus suis T15]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT250556 WP_012775104.1 NZ_CP100432:1110085-1110336 [Streptococcus suis T15]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References