Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 1904244..1905676 | Replicon | chromosome |
| Accession | NZ_CP100431 | ||
| Organism | Streptococcus suis strain 1521251 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | A0A0Z8TB64 |
| Locus tag | NLY77_RS09540 | Protein ID | WP_024394846.1 |
| Coordinates | 1904831..1905676 (+) | Length | 282 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | A0A0Z8SSH7 |
| Locus tag | NLY77_RS09535 | Protein ID | WP_002935109.1 |
| Coordinates | 1904244..1904834 (+) | Length | 197 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLY77_RS09510 (NLY77_09510) | 1900331..1901512 | - | 1182 | WP_254410577.1 | ABC transporter transmembrane domain-containing protein | - |
| NLY77_RS09515 (NLY77_09515) | 1901715..1901906 | - | 192 | WP_002935101.1 | hypothetical protein | - |
| NLY77_RS09520 (NLY77_09520) | 1901995..1902267 | - | 273 | WP_002935103.1 | DUF3884 family protein | - |
| NLY77_RS09525 (NLY77_09525) | 1902296..1903612 | - | 1317 | WP_002935107.1 | glycosyltransferase family 2 protein | - |
| NLY77_RS09530 (NLY77_09530) | 1903800..1903961 | - | 162 | WP_002935108.1 | agglutinin receptor | - |
| NLY77_RS09535 (NLY77_09535) | 1904244..1904834 | + | 591 | WP_002935109.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| NLY77_RS09540 (NLY77_09540) | 1904831..1905676 | + | 846 | WP_024394846.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NLY77_RS09545 (NLY77_09545) | 1905738..1908539 | - | 2802 | WP_254410578.1 | phage tail tip lysozyme | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1821254..1948173 | 126919 | |
| - | flank | IS/Tn | - | - | 1899243..1900247 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 282 a.a. Molecular weight: 32466.18 Da Isoelectric Point: 5.4404
>T250554 WP_024394846.1 NZ_CP100431:1904831-1905676 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD
Download Length: 846 bp
Antitoxin
Download Length: 197 a.a. Molecular weight: 23299.86 Da Isoelectric Point: 7.8482
>AT250554 WP_002935109.1 NZ_CP100431:1904244-1904834 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV
Download Length: 591 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Z8TB64 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Z8SSH7 |