Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 978758..980001 | Replicon | chromosome |
| Accession | NZ_CP100431 | ||
| Organism | Streptococcus suis strain 1521251 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | NLY77_RS04985 | Protein ID | WP_001235242.1 |
| Coordinates | 978758..979525 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | NLY77_RS04990 | Protein ID | WP_000578719.1 |
| Coordinates | 979525..980001 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLY77_RS04970 (NLY77_04970) | 975163..975528 | - | 366 | WP_014636932.1 | MobC family plasmid mobilization relaxosome protein | - |
| NLY77_RS04975 (NLY77_04975) | 975535..975897 | - | 363 | WP_014636933.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| NLY77_RS04980 (NLY77_04980) | 976214..978757 | - | 2544 | WP_000601012.1 | AAA family ATPase | - |
| NLY77_RS04985 (NLY77_04985) | 978758..979525 | - | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NLY77_RS04990 (NLY77_04990) | 979525..980001 | - | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NLY77_RS04995 (NLY77_04995) | 980071..980361 | - | 291 | WP_172008909.1 | hypothetical protein | - |
| NLY77_RS05000 (NLY77_05000) | 980411..980800 | - | 390 | WP_000048066.1 | DUF5945 family protein | - |
| NLY77_RS05005 (NLY77_05005) | 980797..981024 | - | 228 | WP_000110922.1 | DUF5965 family protein | - |
| NLY77_RS05010 (NLY77_05010) | 981052..982152 | - | 1101 | WP_000196860.1 | toprim domain-containing protein | - |
| NLY77_RS05015 (NLY77_05015) | 982216..983859 | - | 1644 | WP_002935076.1 | recombinase family protein | - |
| NLY77_RS05020 (NLY77_05020) | 983985..984881 | + | 897 | WP_001809760.1 | ParA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | erm(B) / tet(O) | - | 971177..995847 | 24670 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T250553 WP_001235242.1 NZ_CP100431:c979525-978758 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT250553 WP_000578719.1 NZ_CP100431:c980001-979525 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|