Detailed information of TA system TA025055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 509476..510124
• Replicon: chromosome
• Accession: NC_014922
• Organism: Haemophilus influenzae F3047

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0Y7JUP0
• Locus tag: HICON_RS02510
• Protein ID: WP_005694481.1
• Coordinates: 509476..509835 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: HICON_RS02515
• Protein ID: WP_005650837.1
• Coordinates: 509828..510124 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HICON_RS02505	506263..509206	+	2944	Protein_482	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
HICON_RS02510	509476..509835	+	360	WP_005694481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HICON_RS02515	509828..510124	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
HICON_RS02520	510285..512201	+	1917	WP_013527363.1	ABC transporter ATP-binding protein	-
HICON_RS02525	512211..512747	+	537	WP_013527364.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
HICON_RS02530	512763..513314	+	552	WP_013527365.1	Sua5/YciO/YrdC/YwlC family protein	-
HICON_RS02535	513318..514124	+	807	WP_013527366.1	shikimate dehydrogenase	-
HICON_RS02540	514136..514888	+	753	WP_006995313.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14321.67 Da
• Isoelectric Point: 10.1408

>T25055 WP_005694481.1 NC_014922:509476-509835 [Haemophilus influenzae F3047]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T25055 NC_014922:509476-509835 [Haemophilus influenzae F3047]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGACAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT25055 WP_005650837.1 NC_014922:509828-510124 [Haemophilus influenzae F3047]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT25055 NC_014922:509828-510124 [Haemophilus influenzae F3047]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTTGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0Y7JUP0