Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1036150..1037420 | Replicon | chromosome |
| Accession | NZ_CP100430 | ||
| Organism | Streptococcus suis strain LSS42 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | A0A0Z8INM2 |
| Locus tag | NLY76_RS04980 | Protein ID | WP_024409332.1 |
| Coordinates | 1036626..1037420 (+) | Length | 265 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | NLY76_RS04975 | Protein ID | WP_024409333.1 |
| Coordinates | 1036150..1036626 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLY76_RS04935 (NLY76_04935) | 1031574..1032521 | + | 948 | WP_226960637.1 | helicase SNF2 | - |
| NLY76_RS04940 (NLY76_04940) | 1032591..1032890 | + | 300 | WP_024382151.1 | DUF5962 family protein | - |
| NLY76_RS04945 (NLY76_04945) | 1032905..1033195 | + | 291 | WP_024409338.1 | DUF5966 family protein | - |
| NLY76_RS04950 (NLY76_04950) | 1033306..1033944 | + | 639 | WP_044769860.1 | hypothetical protein | - |
| NLY76_RS04955 (NLY76_04955) | 1033984..1035072 | + | 1089 | WP_024409336.1 | toprim domain-containing protein | - |
| NLY76_RS04960 (NLY76_04960) | 1035126..1035353 | + | 228 | WP_024409335.1 | DUF5965 family protein | - |
| NLY76_RS04965 (NLY76_04965) | 1035357..1035752 | + | 396 | WP_017285409.1 | DUF5945 family protein | - |
| NLY76_RS04970 (NLY76_04970) | 1035796..1036080 | + | 285 | WP_024409334.1 | hypothetical protein | - |
| NLY76_RS04975 (NLY76_04975) | 1036150..1036626 | + | 477 | WP_024409333.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NLY76_RS04980 (NLY76_04980) | 1036626..1037420 | + | 795 | WP_024409332.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NLY76_RS04985 (NLY76_04985) | 1037401..1039434 | + | 2034 | WP_044678920.1 | ATP-dependent endonuclease | - |
| NLY76_RS04990 (NLY76_04990) | 1039416..1041341 | + | 1926 | WP_044769862.1 | ATP-dependent helicase | - |
| NLY76_RS04995 (NLY76_04995) | 1041388..1041972 | + | 585 | WP_228480237.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 265 a.a. Molecular weight: 30360.57 Da Isoelectric Point: 6.6151
>T250547 WP_024409332.1 NZ_CP100430:1036626-1037420 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
Download Length: 795 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18119.46 Da Isoelectric Point: 4.3193
>AT250547 WP_024409333.1 NZ_CP100430:1036150-1036626 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|