Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2802875..2803651 Replicon chromosome
Accession NZ_CP100428
Organism Staphylococcus aureus strain RMSA24

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NLG45_RS14040 Protein ID WP_000031108.1
Coordinates 2803499..2803651 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NLG45_RS14035 Protein ID WP_001251224.1
Coordinates 2802875..2803474 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG45_RS14015 (NLG45_14015) 2798790..2800247 + 1458 WP_000649907.1 ABC transporter permease subunit -
NLG45_RS14020 (NLG45_14020) 2800240..2800962 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NLG45_RS14025 (NLG45_14025) 2801114..2802241 + 1128 WP_254414343.1 tRNA epoxyqueuosine(34) reductase QueG -
NLG45_RS14030 (NLG45_14030) 2802246..2802716 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NLG45_RS14035 (NLG45_14035) 2802875..2803474 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NLG45_RS14040 (NLG45_14040) 2803499..2803651 + 153 WP_000031108.1 SAS053 family protein Toxin
NLG45_RS14045 (NLG45_14045) 2804195..2804590 + 396 WP_000901023.1 hypothetical protein -
NLG45_RS14050 (NLG45_14050) 2804786..2806171 + 1386 WP_000116229.1 class II fumarate hydratase -
NLG45_RS14055 (NLG45_14055) 2806623..2807444 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T250544 WP_000031108.1 NZ_CP100428:2803499-2803651 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT250544 WP_001251224.1 NZ_CP100428:2802875-2803474 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References