Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2635504..2636033 Replicon chromosome
Accession NZ_CP100428
Organism Staphylococcus aureus strain RMSA24

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NLG45_RS13080 Protein ID WP_000621175.1
Coordinates 2635671..2636033 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NLG45_RS13075 Protein ID WP_000948331.1
Coordinates 2635504..2635674 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG45_RS13045 (NLG45_13045) 2630540..2631100 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
NLG45_RS13050 (NLG45_13050) 2631309..2631788 + 480 WP_001287079.1 hypothetical protein -
NLG45_RS13055 (NLG45_13055) 2631781..2633364 + 1584 WP_001294622.1 PH domain-containing protein -
NLG45_RS13060 (NLG45_13060) 2633351..2633842 + 492 WP_001205912.1 PH domain-containing protein -
NLG45_RS13065 (NLG45_13065) 2633846..2634205 + 360 WP_000581197.1 holo-ACP synthase -
NLG45_RS13070 (NLG45_13070) 2634271..2635419 + 1149 WP_001281154.1 alanine racemase -
NLG45_RS13075 (NLG45_13075) 2635504..2635674 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NLG45_RS13080 (NLG45_13080) 2635671..2636033 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NLG45_RS13085 (NLG45_13085) 2636383..2637384 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NLG45_RS13090 (NLG45_13090) 2637503..2637829 + 327 WP_001052491.1 anti-sigma factor antagonist -
NLG45_RS13095 (NLG45_13095) 2637831..2638310 + 480 WP_001190829.1 anti-sigma B factor RsbW -
NLG45_RS13100 (NLG45_13100) 2638285..2639055 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T250543 WP_000621175.1 NZ_CP100428:2635671-2636033 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT250543 WP_000948331.1 NZ_CP100428:2635504-2635674 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References