Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2615765..2616279 Replicon chromosome
Accession NZ_CP100428
Organism Staphylococcus aureus strain RMSA24

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag NLG45_RS12990 Protein ID WP_000581794.1
Coordinates 2616070..2616279 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NLG45_RS12985 Protein ID WP_000138932.1
Coordinates 2615765..2616058 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG45_RS12965 (NLG45_12965) 2611235..2611876 + 642 WP_000483153.1 thiamine phosphate synthase -
NLG45_RS12970 (NLG45_12970) 2611962..2612834 + 873 WP_000725802.1 membrane protein insertase YidC -
NLG45_RS12975 (NLG45_12975) 2613439..2614086 - 648 WP_001187630.1 HD domain-containing protein -
NLG45_RS12980 (NLG45_12980) 2614114..2615599 - 1486 Protein_2549 cardiolipin synthase -
NLG45_RS12985 (NLG45_12985) 2615765..2616058 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NLG45_RS12990 (NLG45_12990) 2616070..2616279 + 210 WP_000581794.1 heavy metal-associated domain-containing protein Toxin
NLG45_RS12995 (NLG45_12995) 2616407..2616544 + 138 WP_000828354.1 Lmo0850 family protein -
NLG45_RS13000 (NLG45_13000) 2616808..2618010 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NLG45_RS13005 (NLG45_13005) 2618328..2619398 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NLG45_RS13010 (NLG45_13010) 2619413..2620771 + 1359 WP_254414340.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7833.73 Da        Isoelectric Point: 4.1008

>T250542 WP_000581794.1 NZ_CP100428:2616070-2616279 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETSANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT250542 WP_000138932.1 NZ_CP100428:2615765-2616058 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References