Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 194326..194957 Replicon chromosome
Accession NC_014922
Organism Haemophilus influenzae F3047

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag HICON_RS00895 Protein ID WP_005651560.1
Coordinates 194559..194957 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag HICON_RS00890 Protein ID WP_005648011.1
Coordinates 194326..194559 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HICON_RS00865 189805..191007 - 1203 WP_006995609.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
HICON_RS00870 191171..191836 + 666 WP_013527272.1 DNA repair protein RadC -
HICON_RS00875 192050..192286 + 237 WP_006995608.1 50S ribosomal protein L28 -
HICON_RS00880 192298..192468 + 171 WP_005613503.1 50S ribosomal protein L33 -
HICON_RS00885 192815..194179 + 1365 WP_006995606.1 diaminobutyrate--2-oxoglutarate transaminase -
HICON_RS00890 194326..194559 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
HICON_RS00895 194559..194957 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
HICON_RS00900 194977..196512 + 1536 WP_006995605.1 L-2,4-diaminobutyrate decarboxylase -
HICON_RS00905 196771..197586 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
HICON_RS00910 197660..198682 - 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
HICON_RS00915 198683..199801 - 1119 WP_006995603.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T25054 WP_005651560.1 NC_014922:194559-194957 [Haemophilus influenzae F3047]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T25054 NC_014922:194559-194957 [Haemophilus influenzae F3047]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT25054 WP_005648011.1 NC_014922:194326-194559 [Haemophilus influenzae F3047]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT25054 NC_014922:194326-194559 [Haemophilus influenzae F3047]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References