Detailed information of TA system TA250533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 743379..745207
• Replicon: chromosome
• Accession: NZ_CP100422
• Organism: Vibrio furnissii strain 104486766

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: NIN90_RS03490
• Protein ID: WP_167394138.1
• Coordinates: 743846..745207 (-)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: NIN90_RS03485
• Protein ID: WP_029786578.1
• Coordinates: 743379..743861 (-)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIN90_RS03480	740916..742391	-	1476	WP_254413630.1	dGTPase	-
NIN90_RS03485	743379..743861	-	483	WP_029786578.1	helix-turn-helix transcriptional regulator	Antitoxin
NIN90_RS03490	743846..745207	-	1362	WP_167394138.1	type II toxin-antitoxin system HipA family toxin	Toxin
NIN90_RS03495	745698..746480	-	783	WP_104971326.1	metallophosphoesterase	-
NIN90_RS03500	747085..747471	-	387	WP_104971327.1	transcriptional regulator	-
NIN90_RS03505	747721..749493	+	1773	WP_104971328.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-139)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51412.12 Da
• Isoelectric Point: 4.8182

>T250533 WP_167394138.1 NZ_CP100422:c745207-743846 [Vibrio furnissii]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRVKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLVLRGVPEQILEMPAVGLNHISEKLTKWGLL

Nucleotide

• Length: 1362 bp

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17535.05 Da
• Isoelectric Point: 10.8446

>AT250533 WP_029786578.1 NZ_CP100422:c743861-743379 [Vibrio furnissii]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Nucleotide

• Length: 483 bp