250532

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1806249..1806885 Replicon chromosome
Accession NZ_CP100420
Organism Niallia sp. RD1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NKG37_RS08570 Protein ID WP_169187740.1
Coordinates 1806535..1806885 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R9CA23
Locus tag NKG37_RS08565 Protein ID WP_016201247.1
Coordinates 1806249..1806530 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKG37_RS08545 (NKG37_08545) 1801717..1802442 - 726 WP_212119571.1 rhomboid family intramembrane serine protease -
NKG37_RS08550 (NKG37_08550) 1802550..1802900 + 351 WP_254416078.1 holo-ACP synthase -
NKG37_RS08555 (NKG37_08555) 1803513..1804523 + 1011 WP_254416079.1 outer membrane lipoprotein carrier protein LolA -
NKG37_RS08560 (NKG37_08560) 1804739..1805896 + 1158 WP_254416080.1 alanine racemase -
NKG37_RS08565 (NKG37_08565) 1806249..1806530 + 282 WP_016201247.1 CopG family ribbon-helix-helix protein Antitoxin
NKG37_RS08570 (NKG37_08570) 1806535..1806885 + 351 WP_169187740.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NKG37_RS08575 (NKG37_08575) 1807727..1808092 + 366 WP_016201244.1 STAS domain-containing protein -
NKG37_RS08580 (NKG37_08580) 1808096..1808497 + 402 WP_254416081.1 anti-sigma regulatory factor -
NKG37_RS08585 (NKG37_08585) 1808509..1809519 + 1011 WP_016201242.1 PP2C family protein-serine/threonine phosphatase -
NKG37_RS08590 (NKG37_08590) 1809575..1809907 + 333 WP_016201241.1 anti-sigma factor antagonist -
NKG37_RS08595 (NKG37_08595) 1809904..1810374 + 471 WP_016201240.1 anti-sigma B factor RsbW -
NKG37_RS08600 (NKG37_08600) 1810352..1811149 + 798 WP_016201239.1 RNA polymerase sigma factor SigB -
NKG37_RS08605 (NKG37_08605) 1811146..1811742 + 597 WP_016201238.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.05 Da        Isoelectric Point: 5.1771

>T250532 WP_169187740.1 NZ_CP100420:1806535-1806885 [Niallia sp. RD1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEGMMEKVDEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10839.44 Da        Isoelectric Point: 8.4775

>AT250532 WP_016201247.1 NZ_CP100420:1806249-1806530 [Niallia sp. RD1]
VSESSATTEIMIKLPKHLLTELDGFVKQENVNRSEFIYQATKMYLRERKKRHIRESMRRGYMEMAKLNLSIASESFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R9CA23

References