Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 1286957..1288200 | Replicon | chromosome |
| Accession | NZ_CP100418 | ||
| Organism | Streptococcus suis strain STC104 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | NLY35_RS06415 | Protein ID | WP_001235242.1 |
| Coordinates | 1286957..1287724 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | NLY35_RS06420 | Protein ID | WP_000578719.1 |
| Coordinates | 1287724..1288200 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLY35_RS06400 (NLY35_06400) | 1283345..1283710 | - | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
| NLY35_RS06405 (NLY35_06405) | 1283713..1284075 | - | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| NLY35_RS06410 (NLY35_06410) | 1284413..1286956 | - | 2544 | WP_254379776.1 | AAA family ATPase | - |
| NLY35_RS06415 (NLY35_06415) | 1286957..1287724 | - | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NLY35_RS06420 (NLY35_06420) | 1287724..1288200 | - | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NLY35_RS06425 (NLY35_06425) | 1288270..1288560 | - | 291 | WP_000667951.1 | hypothetical protein | - |
| NLY35_RS06430 (NLY35_06430) | 1288611..1289000 | - | 390 | WP_000048066.1 | DUF5945 family protein | - |
| NLY35_RS06435 (NLY35_06435) | 1288997..1289224 | - | 228 | WP_000110922.1 | DUF5965 family protein | - |
| NLY35_RS06440 (NLY35_06440) | 1289252..1290352 | - | 1101 | WP_000196860.1 | toprim domain-containing protein | - |
| NLY35_RS06445 (NLY35_06445) | 1290416..1292059 | - | 1644 | WP_004607528.1 | recombinase family protein | - |
| NLY35_RS06450 (NLY35_06450) | 1292150..1293046 | + | 897 | WP_001809760.1 | ParA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | erm(B) / tet(O) | - | 1271890..1303990 | 32100 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T250528 WP_001235242.1 NZ_CP100418:c1287724-1286957 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT250528 WP_000578719.1 NZ_CP100418:c1288200-1287724 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|