Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 971934..972435 Replicon chromosome
Accession NZ_CP100418
Organism Streptococcus suis strain STC104

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NLY35_RS04945 Protein ID WP_024405694.1
Coordinates 971934..972200 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NLY35_RS04950 Protein ID WP_024417206.1
Coordinates 972184..972435 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY35_RS04925 (NLY35_04925) 967565..968635 + 1071 WP_014636926.1 tyrosine recombinase XerS -
NLY35_RS04930 (NLY35_04930) 968705..970213 - 1509 WP_172001163.1 phosphomannomutase/phosphoglucomutase -
NLY35_RS04935 (NLY35_04935) 970289..971230 - 942 WP_024417207.1 sensor histidine kinase -
NLY35_RS04940 (NLY35_04940) 971227..971892 - 666 WP_024405695.1 response regulator transcription factor -
NLY35_RS04945 (NLY35_04945) 971934..972200 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLY35_RS04950 (NLY35_04950) 972184..972435 - 252 WP_024417206.1 DUF6290 family protein Antitoxin
NLY35_RS04955 (NLY35_04955) 972527..974497 - 1971 WP_024417205.1 ABC transporter permease -
NLY35_RS04960 (NLY35_04960) 974498..975250 - 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
NLY35_RS04965 (NLY35_04965) 975271..975648 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NLY35_RS04970 (NLY35_04970) 975661..975801 - 141 WP_012775106.1 hypothetical protein -
NLY35_RS04975 (NLY35_04975) 975941..977107 - 1167 WP_024417204.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 909360..1060600 151240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T250527 WP_024405694.1 NZ_CP100418:c972200-971934 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9452.70 Da        Isoelectric Point: 3.7952

>AT250527 WP_024417206.1 NZ_CP100418:c972435-972184 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure

References