250525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5560283..5560853 Replicon chromosome
Accession NZ_CP100397
Organism Streptomyces rimosus subsp. rimosus strain HP126

Toxin (Protein)


Gene name mazF Uniprot ID L8ERH5
Locus tag SRIMHP_RS24190 Protein ID WP_003982453.1
Coordinates 5560506..5560853 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID L8ERT3
Locus tag SRIMHP_RS24185 Protein ID WP_003982452.1
Coordinates 5560283..5560519 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRIMHP_RS24170 (SRIMHP_24265) 5555705..5556862 + 1158 WP_003982449.1 allantoicase -
SRIMHP_RS24175 (SRIMHP_24270) 5556934..5559510 - 2577 WP_003982450.1 aminopeptidase N -
SRIMHP_RS24180 (SRIMHP_24275) 5559644..5560243 + 600 WP_003982451.1 Uma2 family endonuclease -
SRIMHP_RS24185 (SRIMHP_24280) 5560283..5560519 + 237 WP_003982452.1 ribbon-helix-helix domain-containing protein Antitoxin
SRIMHP_RS24190 (SRIMHP_24285) 5560506..5560853 + 348 WP_003982453.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SRIMHP_RS24195 (SRIMHP_24290) 5560934..5561455 + 522 WP_003982454.1 DUF1203 domain-containing protein -
SRIMHP_RS24200 (SRIMHP_24295) 5561526..5562557 - 1032 WP_003982455.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12493.43 Da        Isoelectric Point: 10.8691

>T250525 WP_003982453.1 NZ_CP100397:5560506-5560853 [Streptomyces rimosus subsp. rimosus]
MRRGDLYLVDLEPVRGSEANKYRPAVVVSNDAANRSVQRAGRGVVTVVPVTANVARVYPFQVLLTADDCGLPRDSKAQCE
QVRAVSVERLGRRVGSVPARVMVGLDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8374.07 Da        Isoelectric Point: 3.7856

>AT250525 WP_003982452.1 NZ_CP100397:5560283-5560519 [Streptomyces rimosus subsp. rimosus]
MKISVSLPEEDIAFLDAYGKKTDADSRSAVIHAAVELLRASELEADYASAWEEWDESDDALLWDGVSGDGIGSADAAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8ERH5

Antitoxin

Source ID Structure
AlphaFold DB L8ERT3

References