Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2890428..2890953 Replicon chromosome
Accession NZ_CP100397
Organism Streptomyces rimosus subsp. rimosus strain HP126

Toxin (Protein)


Gene name relE Uniprot ID L8EGB8
Locus tag SRIMHP_RS11890 Protein ID WP_003987428.1
Coordinates 2890690..2890953 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L8ED57
Locus tag SRIMHP_RS11885 Protein ID WP_003987429.1
Coordinates 2890428..2890697 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRIMHP_RS11860 (SRIMHP_11930) 2885460..2886182 + 723 WP_030181983.1 PIG-L deacetylase family protein -
SRIMHP_RS11865 (SRIMHP_11935) 2886170..2887138 - 969 WP_003982326.1 alpha/beta hydrolase -
SRIMHP_RS11870 (SRIMHP_11940) 2887268..2887777 + 510 WP_003982327.1 hypothetical protein -
SRIMHP_RS11875 (SRIMHP_11945) 2887818..2888402 + 585 WP_003982328.1 Uma2 family endonuclease -
SRIMHP_RS11880 (SRIMHP_11950) 2888444..2890124 - 1681 Protein_2360 IS1182-like element ISSdi1 family transposase -
SRIMHP_RS11885 (SRIMHP_11960) 2890428..2890697 + 270 WP_003987429.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SRIMHP_RS11890 (SRIMHP_11965) 2890690..2890953 + 264 WP_003987428.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRIMHP_RS11895 (SRIMHP_11970) 2891088..2892176 - 1089 WP_003987427.1 redox-regulated ATPase YchF -
SRIMHP_RS11900 (SRIMHP_11975) 2892719..2893426 + 708 WP_063604328.1 hypothetical protein -
SRIMHP_RS11905 (SRIMHP_11980) 2893392..2894264 - 873 WP_078586864.1 ROK family protein -
SRIMHP_RS11910 (SRIMHP_11985) 2894350..2895393 - 1044 WP_078586862.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-56)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10084.54 Da        Isoelectric Point: 8.5041

>T250524 WP_003987428.1 NZ_CP100397:2890690-2890953 [Streptomyces rimosus subsp. rimosus]
VSEYRTVFRPEAQTELRKVPRDMALRILAKLTELETDPLGFNTTALVSQPDRRRLRVGDYRLIYTIDNGELVVWVVHVGH
RSTVYDA

Download         Length: 264 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10290.73 Da        Isoelectric Point: 4.7473

>AT250524 WP_003987429.1 NZ_CP100397:2890428-2890697 [Streptomyces rimosus subsp. rimosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIETLRKYQEWEEREINRIIDERMANPAPGIPLEDI
MRETLARSE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8EGB8

Antitoxin

Source ID Structure
AlphaFold DB L8ED57

References