250523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 20297..20990 Replicon plasmid pFAHZZU2447_NDM
Accession NZ_CP100393
Organism Aeromonas caviae strain FAHZZU2447

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag NJR02_RS21325 Protein ID WP_000182276.1
Coordinates 20297..20653 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag NJR02_RS21330 Protein ID WP_001172026.1
Coordinates 20655..20990 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJR02_RS21310 (NJR02_21310) 15408..16253 - 846 WP_003464995.1 AraC family transcriptional regulator -
NJR02_RS21315 (NJR02_21315) 16490..19519 - 3030 WP_032432545.1 Tn3 family transposase -
NJR02_RS21320 (NJR02_21320) 19503..20105 - 603 WP_010465829.1 recombinase family protein -
NJR02_RS21325 (NJR02_21325) 20297..20653 + 357 WP_000182276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NJR02_RS21330 (NJR02_21330) 20655..20990 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
NJR02_RS21335 (NJR02_21335) 21005..21340 + 336 WP_000741275.1 hypothetical protein -
NJR02_RS21340 (NJR02_21340) 21364..21690 + 327 WP_000091614.1 hypothetical protein -
NJR02_RS21345 (NJR02_21345) 21687..22067 + 381 WP_001054412.1 hypothetical protein -
NJR02_RS21350 (NJR02_21350) 22185..23451 + 1267 Protein_28 HD-GYP domain-containing protein -
NJR02_RS21355 (NJR02_21355) 23735..24013 + 279 WP_010465808.1 hypothetical protein -
NJR02_RS21360 (NJR02_21360) 24054..24179 - 126 Protein_30 mercuric transport protein periplasmic component -
NJR02_RS21365 (NJR02_21365) 24193..24543 - 351 WP_001294663.1 mercuric transport protein MerT -
NJR02_RS21370 (NJR02_21370) 24615..25049 + 435 WP_000429836.1 Hg(II)-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / aph(6)-Id / aph(3'')-Ib / aac(3)-IId / dfrA5 / qacE / sul1 / blaNDM-1 / blaOXA-427 / mph(A) - 1..243752 243752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12912.93 Da        Isoelectric Point: 8.9018

>T250523 WP_000182276.1 NZ_CP100393:20297-20653 [Aeromonas caviae]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Download         Length: 357 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT250523 WP_001172026.1 NZ_CP100393:20655-20990 [Aeromonas caviae]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References