250522

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2585611..2587175 Replicon chromosome
Accession NZ_CP100392
Organism Aeromonas caviae strain FAHZZU2447

Toxin (Protein)


Gene name hipA Uniprot ID A0A2L0TXX7
Locus tag NJR02_RS11940 Protein ID WP_059169586.1
Coordinates 2585865..2587175 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NJR02_RS11935 Protein ID WP_005329233.1
Coordinates 2585611..2585865 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJR02_RS11910 (NJR02_11910) 2581186..2581764 - 579 WP_021140685.1 hypothetical protein -
NJR02_RS11915 (NJR02_11915) 2582096..2582548 - 453 WP_021140686.1 DUF2384 domain-containing protein -
NJR02_RS11920 (NJR02_11920) 2582803..2584110 + 1308 WP_021140687.1 Fic family protein -
NJR02_RS11925 (NJR02_11925) 2584189..2584440 + 252 WP_010674977.1 plasmid stabilization protein -
NJR02_RS11930 (NJR02_11930) 2584861..2585109 - 249 WP_010674978.1 hypothetical protein -
NJR02_RS11935 (NJR02_11935) 2585611..2585865 + 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
NJR02_RS11940 (NJR02_11940) 2585865..2587175 + 1311 WP_059169586.1 type II toxin-antitoxin system HipA family toxin Toxin
NJR02_RS11950 (NJR02_11950) 2588131..2590305 + 2175 WP_104453007.1 catalase/peroxidase HPI -
NJR02_RS11955 (NJR02_11955) 2590406..2591170 - 765 WP_104453008.1 DeoR/GlpR family DNA-binding transcription regulator -
NJR02_RS11960 (NJR02_11960) 2591214..2591441 - 228 WP_199770477.1 HAD hydrolase family protein -
NJR02_RS11965 (NJR02_11965) 2591451..2591843 - 393 WP_199770478.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49136.32 Da        Isoelectric Point: 7.1717

>T250522 WP_059169586.1 NZ_CP100392:2585865-2587175 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKTIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSRAQRLKR

Download         Length: 1311 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT250522 WP_005329233.1 NZ_CP100392:2585611-2585865 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0TXX7

Antitoxin

Source ID Structure

References