250520

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2690313..2691230 Replicon chromosome
Accession NZ_CP100391
Organism Bacillus velezensis strain PHP1601

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag NJ242_RS12970 Protein ID WP_007407256.1
Coordinates 2690313..2691059 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NJ242_RS12975 Protein ID WP_003154807.1
Coordinates 2691060..2691230 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJ242_RS12950 (NJ242_12950) 2685706..2686656 - 951 WP_032874618.1 ring-cleaving dioxygenase -
NJ242_RS12955 (NJ242_12955) 2686978..2688294 + 1317 WP_032874616.1 amino acid permease -
NJ242_RS12960 (NJ242_12960) 2688580..2689197 + 618 WP_032874614.1 DUF47 domain-containing protein -
NJ242_RS12965 (NJ242_12965) 2689210..2690208 + 999 WP_032874611.1 inorganic phosphate transporter -
NJ242_RS12970 (NJ242_12970) 2690313..2691059 + 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NJ242_RS12975 (NJ242_12975) 2691060..2691230 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NJ242_RS12980 (NJ242_12980) 2691327..2691452 + 126 WP_003154809.1 hypothetical protein -
NJ242_RS12985 (NJ242_12985) 2691487..2692365 - 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
NJ242_RS12990 (NJ242_12990) 2692379..2692642 - 264 WP_003154813.1 phage holin -
NJ242_RS12995 (NJ242_12995) 2692656..2692919 - 264 WP_003154815.1 hemolysin XhlA family protein -
NJ242_RS13000 (NJ242_13000) 2692971..2693732 - 762 WP_032874607.1 hypothetical protein -
NJ242_RS13005 (NJ242_13005) 2693789..2693986 - 198 WP_032874605.1 XkdX family protein -
NJ242_RS13010 (NJ242_13010) 2693991..2694362 - 372 WP_032874603.1 XkdW family protein -
NJ242_RS13015 (NJ242_13015) 2694375..2695997 - 1623 WP_032874601.1 pyocin knob domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T250520 WP_007407256.1 NZ_CP100391:2690313-2691059 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT250520 WP_003154807.1 NZ_CP100391:2691060-2691230 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References