Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2160575..2161323 Replicon chromosome
Accession NZ_CP100390
Organism Alkalimarinus sp. A2M4

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NKI27_RS09760 Protein ID WP_265045873.1
Coordinates 2160575..2161060 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NKI27_RS09765 Protein ID WP_265045874.1
Coordinates 2161048..2161323 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKI27_RS09745 (NKI27_09730) 2156305..2157246 - 942 WP_265045870.1 SDR family oxidoreductase -
NKI27_RS09750 (NKI27_09735) 2157246..2158061 - 816 WP_265045871.1 lysophospholipid acyltransferase family protein -
NKI27_RS09755 (NKI27_09740) 2158383..2159567 + 1185 WP_265045872.1 tyrosine-type recombinase/integrase -
NKI27_RS09760 (NKI27_09745) 2160575..2161060 - 486 WP_265045873.1 GNAT family N-acetyltransferase Toxin
NKI27_RS09765 (NKI27_09750) 2161048..2161323 - 276 WP_265045874.1 DUF1778 domain-containing protein Antitoxin
NKI27_RS09770 (NKI27_09755) 2161530..2161817 - 288 WP_265045875.1 hypothetical protein -
NKI27_RS09775 (NKI27_09760) 2161902..2162657 - 756 WP_265045876.1 metallophosphoesterase -
NKI27_RS09780 (NKI27_09765) 2162710..2162901 - 192 WP_265045877.1 hypothetical protein -
NKI27_RS09785 (NKI27_09770) 2162974..2163117 + 144 WP_265045878.1 P-loop NTPase -
NKI27_RS09790 (NKI27_09775) 2163136..2163528 + 393 WP_265045879.1 hypothetical protein -
NKI27_RS09795 (NKI27_09780) 2163607..2163819 + 213 WP_265045880.1 hypothetical protein -
NKI27_RS09800 (NKI27_09785) 2163992..2164258 + 267 WP_265045881.1 hypothetical protein -
NKI27_RS09805 (NKI27_09790) 2164360..2164716 + 357 WP_265045882.1 hypothetical protein -
NKI27_RS09810 (NKI27_09795) 2164771..2165058 + 288 WP_265045883.1 hypothetical protein -
NKI27_RS09815 (NKI27_09800) 2165058..2165411 + 354 WP_265045884.1 IS66 family insertion sequence element accessory protein TnpB -
NKI27_RS09820 (NKI27_09805) 2165404..2165607 + 204 WP_265045885.1 hypothetical protein -
NKI27_RS09825 (NKI27_09810) 2165573..2165983 + 411 WP_265045886.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - xcpR / xcpT 2099354..2482404 383050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-84)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 18086.14 Da        Isoelectric Point: 9.7903

>T250519 WP_265045873.1 NZ_CP100390:c2161060-2160575 [Alkalimarinus sp. A2M4]
MGRISKPEPLRSVHDLSRFSCGIDSLDQWLKTRALKNERINASRTYVVCDELRVAGYYCLATGSIEHNESPSKVKRNMPS
PIPVMILGRLAVDIDYQDQKIGKGLLKDAVLRTILISEQVGVKAMLVHAINDSARYFYKAHGFIESPFDPMKLLLPTAKK
V

Download         Length: 486 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10400.87 Da        Isoelectric Point: 4.6677

>AT250519 WP_265045874.1 NZ_CP100390:c2161323-2161048 [Alkalimarinus sp. A2M4]
MTKAIHKVPINMRADEDLRNLIDQAAAISSKDRTSFILETMRRESENIILDQRLFKLDEEAFSQLDELISVPISSNPALT
KLLSSKSPWEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References