Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1212214..1212724 Replicon chromosome
Accession NZ_CP100390
Organism Alkalimarinus sp. A2M4

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag NKI27_RS05330 Protein ID WP_265048652.1
Coordinates 1212461..1212724 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8G613
Locus tag NKI27_RS05325 Protein ID WP_015486388.1
Coordinates 1212214..1212468 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKI27_RS05305 (NKI27_05310) 1207227..1209002 + 1776 WP_265048649.1 sodium:solute symporter family protein -
NKI27_RS05310 (NKI27_05315) 1209049..1210032 - 984 WP_265048650.1 integron integrase -
NKI27_RS05315 (NKI27_05320) 1210405..1210944 + 540 WP_265048651.1 manganese efflux pump MntP family protein -
NKI27_RS05320 (NKI27_05325) 1211494..1212033 + 540 WP_265049473.1 DUF4124 domain-containing protein -
NKI27_RS05325 (NKI27_05330) 1212214..1212468 + 255 WP_015486388.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NKI27_RS05330 (NKI27_05335) 1212461..1212724 + 264 WP_265048652.1 Txe/YoeB family addiction module toxin Toxin
NKI27_RS05335 (NKI27_05340) 1212869..1213258 + 390 WP_265048653.1 DUF3465 domain-containing protein -
NKI27_RS05340 (NKI27_05345) 1213367..1213642 + 276 WP_265048654.1 hypothetical protein -
NKI27_RS05345 (NKI27_05350) 1213761..1214546 + 786 WP_265048655.1 NERD domain-containing protein -
NKI27_RS05350 (NKI27_05355) 1215012..1215365 - 354 WP_265048656.1 hypothetical protein -
NKI27_RS05355 (NKI27_05360) 1216875..1217240 + 366 WP_265048657.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1209049..1237047 27998


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10361.76 Da        Isoelectric Point: 9.0098

>T250512 WP_265048652.1 NZ_CP100390:1212461-1212724 [Alkalimarinus sp. A2M4]
MSSRLLCWTDEAWNDYVYWQGQDKKTLKRINKLISDTKRSPFEGIGKPEPLKENLSGFWSRRIDDSNRLVYAVDDKTLTI
ISCRYHY

Download         Length: 264 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9373.51 Da        Isoelectric Point: 5.0481

>AT250512 WP_015486388.1 NZ_CP100390:1212214-1212468 [Alkalimarinus sp. A2M4]
MRVVSFTEARNGLKAVLDSVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLKSPANAEHLNKSIAQYKSGKTTQRD
IVDE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8G613

References