Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4717845..4718461 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ581_RS22360 Protein ID WP_017382676.1
Coordinates 4717845..4718216 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag LZ581_RS22365 Protein ID WP_015569912.1
Coordinates 4718219..4718461 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS22345 (LZ581_22345) 4715345..4716247 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
LZ581_RS22350 (LZ581_22350) 4716244..4716879 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
LZ581_RS22355 (LZ581_22355) 4716876..4717805 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
LZ581_RS22360 (LZ581_22360) 4717845..4718216 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ581_RS22365 (LZ581_22365) 4718219..4718461 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
LZ581_RS22370 (LZ581_22370) 4718660..4719580 + 921 WP_254309470.1 alpha/beta hydrolase -
LZ581_RS22375 (LZ581_22375) 4719589..4720530 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
LZ581_RS22380 (LZ581_22380) 4720575..4721012 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
LZ581_RS22385 (LZ581_22385) 4721009..4721890 - 882 WP_003861949.1 virulence factor BrkB family protein -
LZ581_RS22390 (LZ581_22390) 4721884..4722483 - 600 WP_063413088.1 glucose-1-phosphatase -
LZ581_RS22395 (LZ581_22395) 4722602..4723402 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T250510 WP_017382676.1 NZ_CP100388:c4718216-4717845 [Enterobacter hormaechei subsp. steigerwaltii]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT250510 WP_015569912.1 NZ_CP100388:c4718461-4718219 [Enterobacter hormaechei subsp. steigerwaltii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References