Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1260156..1260803 Replicon chromosome
Accession NC_014920
Organism Haemophilus influenzae F3031

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QVV0
Locus tag HIBPF_RS06340 Protein ID WP_041174961.1
Coordinates 1260627..1260803 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A5T8
Locus tag HIBPF_RS06335 Protein ID WP_013526165.1
Coordinates 1260156..1260572 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIBPF_RS06295 1255383..1257032 - 1650 WP_013526159.1 phage terminase large subunit -
HIBPF_RS06300 1257182..1257682 - 501 WP_013526160.1 DUF1804 family protein -
HIBPF_RS06305 1257684..1257950 - 267 WP_005661915.1 hypothetical protein -
HIBPF_RS06310 1257950..1258207 - 258 WP_005684166.1 hypothetical protein -
HIBPF_RS06315 1258331..1258588 - 258 WP_013526161.1 DUF2681 domain-containing protein -
HIBPF_RS06320 1258588..1258878 - 291 WP_041174960.1 DUF2644 domain-containing protein -
HIBPF_RS06325 1259032..1259535 - 504 WP_013526163.1 glycoside hydrolase family 108 protein -
HIBPF_RS06330 1259616..1260044 - 429 WP_013526164.1 hypothetical protein -
HIBPF_RS06335 1260156..1260572 - 417 WP_013526165.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HIBPF_RS06340 1260627..1260803 - 177 WP_041174961.1 type II toxin-antitoxin system HicA family toxin Toxin
HIBPF_RS06345 1260929..1261147 - 219 WP_005641522.1 hypothetical protein -
HIBPF_RS06350 1261158..1261799 - 642 WP_013526166.1 antA/AntB antirepressor family protein -
HIBPF_RS06355 1262336..1262539 - 204 WP_006996626.1 KilA-N domain-containing protein -
HIBPF_RS06360 1262566..1262964 - 399 WP_013526167.1 regulatory protein GemA -
HIBPF_RS06365 1263205..1263453 - 249 WP_006996624.1 hypothetical protein -
HIBPF_RS06370 1263458..1263631 - 174 WP_006996623.1 hypothetical protein -
HIBPF_RS10590 1263628..1263792 - 165 WP_171034544.1 hypothetical protein -
HIBPF_RS06375 1263803..1264000 - 198 WP_006996621.1 ANR family transcriptional regulator -
HIBPF_RS06380 1264187..1264804 - 618 WP_013526168.1 DUF3164 family protein -
HIBPF_RS06385 1264805..1264996 - 192 WP_005647090.1 HTH domain-containing protein -
HIBPF_RS06390 1265005..1265301 - 297 WP_013526169.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1249277..1280490 31213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-92)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6622.81 Da        Isoelectric Point: 10.6309

>T25051 WP_041174961.1 NC_014920:c1260803-1260627 [Haemophilus influenzae F3031]
VKQSEFLKWLKANGVEVENGSKHLKLYYQGKISHLPRHPAQELKKGLVEGIKKQLGLK

Download         Length: 177 bp

>T25051 NC_014920:c1260803-1260627 [Haemophilus influenzae F3031]
GTGAAACAAAGTGAGTTCCTAAAATGGCTAAAAGCCAATGGGGTTGAAGTTGAAAATGGTTCAAAACATTTGAAACTTTA
CTACCAAGGCAAAATAAGCCACTTACCCCGCCACCCAGCGCAAGAATTGAAAAAGGGTTTGGTGGAAGGGATTAAGAAAC
AGTTAGGATTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15304.57 Da        Isoelectric Point: 4.2525

>AT25051 WP_013526165.1 NC_014920:c1260572-1260156 [Haemophilus influenzae F3031]
MFYPATFTPAEEGGYVVTFADLPEAITQGDTIEEAQEMAEDVLISCVEIYFDEERPFPLARACDSDETAVFMPDSVYAKV
LLHNAMLAENVSKAQLARLTYIRPPEIQRILAPRHTTKIDTIAKALLGLGKQLQLSVV

Download         Length: 417 bp

>AT25051 NC_014920:c1260572-1260156 [Haemophilus influenzae F3031]
ATGTTTTACCCAGCAACCTTTACCCCCGCCGAAGAAGGCGGTTATGTCGTCACCTTTGCAGATTTGCCAGAAGCGATTAC
ACAAGGCGATACCATAGAAGAAGCGCAAGAAATGGCGGAAGATGTGTTGATTTCTTGTGTAGAAATCTACTTTGATGAAG
AACGCCCTTTCCCATTGGCTCGTGCATGCGATAGTGATGAAACTGCGGTATTTATGCCCGATAGCGTGTATGCTAAAGTG
CTGTTGCATAATGCGATGTTGGCAGAAAATGTATCAAAAGCACAATTAGCGCGCTTAACCTATATTCGTCCGCCTGAAAT
TCAGCGTATTCTTGCGCCACGCCATACGACAAAAATTGATACGATTGCCAAAGCATTGTTAGGCTTAGGCAAGCAATTAC
AACTTTCTGTCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QVV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QY11

References