Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3926292..3926949 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LZ581_RS18545 Protein ID WP_017382887.1
Coordinates 3926292..3926702 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LZ581_RS18550 Protein ID WP_003863437.1
Coordinates 3926683..3926949 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS18525 (LZ581_18525) 3922290..3924023 - 1734 WP_126764932.1 single-stranded-DNA-specific exonuclease RecJ -
LZ581_RS18530 (LZ581_18530) 3924029..3924742 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZ581_RS18535 (LZ581_18535) 3924771..3925667 - 897 WP_254309371.1 site-specific tyrosine recombinase XerD -
LZ581_RS18540 (LZ581_18540) 3925769..3926290 + 522 WP_015571793.1 flavodoxin FldB -
LZ581_RS18545 (LZ581_18545) 3926292..3926702 - 411 WP_017382887.1 protein YgfX Toxin
LZ581_RS18550 (LZ581_18550) 3926683..3926949 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LZ581_RS18555 (LZ581_18555) 3927244..3928224 + 981 WP_048219529.1 tRNA-modifying protein YgfZ -
LZ581_RS18560 (LZ581_18560) 3928336..3928995 - 660 WP_003863433.1 hemolysin III family protein -
LZ581_RS18565 (LZ581_18565) 3929262..3929993 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
LZ581_RS18570 (LZ581_18570) 3930110..3931543 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T250508 WP_017382887.1 NZ_CP100388:c3926702-3926292 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT250508 WP_003863437.1 NZ_CP100388:c3926949-3926683 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References