Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2386251..2386990 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag LZ581_RS11320 Protein ID WP_003857133.1
Coordinates 2386251..2386736 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LZ581_RS11325 Protein ID WP_003857131.1
Coordinates 2386724..2386990 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS11290 (LZ581_11290) 2381751..2382365 + 615 WP_080337332.1 NUDIX hydrolase -
LZ581_RS11295 (LZ581_11295) 2382549..2383184 - 636 WP_015570517.1 DUF421 domain-containing protein -
LZ581_RS11300 (LZ581_11300) 2383194..2383640 - 447 WP_014069654.1 DUF3290 domain-containing protein -
LZ581_RS11305 (LZ581_11305) 2383957..2384385 - 429 WP_033487951.1 hypothetical protein -
LZ581_RS11310 (LZ581_11310) 2384650..2385615 + 966 WP_254309784.1 hypothetical protein -
LZ581_RS11315 (LZ581_11315) 2385631..2386200 + 570 WP_032648331.1 hypothetical protein -
LZ581_RS11320 (LZ581_11320) 2386251..2386736 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
LZ581_RS11325 (LZ581_11325) 2386724..2386990 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LZ581_RS11330 (LZ581_11330) 2387054..2387983 - 930 WP_058689393.1 LysR family transcriptional regulator -
LZ581_RS11335 (LZ581_11335) 2388113..2389495 + 1383 WP_047741273.1 MFS transporter -
LZ581_RS11340 (LZ581_11340) 2389517..2390512 - 996 WP_017382342.1 DUF2891 domain-containing protein -
LZ581_RS11345 (LZ581_11345) 2390522..2391508 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2369202..2386990 17788


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T250501 WP_003857133.1 NZ_CP100388:c2386736-2386251 [Enterobacter hormaechei subsp. steigerwaltii]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT250501 WP_003857131.1 NZ_CP100388:c2386990-2386724 [Enterobacter hormaechei subsp. steigerwaltii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References