Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1760718..1761515 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LZ581_RS08250 Protein ID WP_254309704.1
Coordinates 1760994..1761515 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag LZ581_RS08245 Protein ID WP_015570876.1
Coordinates 1760718..1760987 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS08210 (LZ581_08210) 1756260..1756619 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
LZ581_RS08215 (LZ581_08215) 1756691..1756792 - 102 Protein_1595 transcriptional regulator -
LZ581_RS08220 (LZ581_08220) 1756945..1758186 + 1242 WP_254309703.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
LZ581_RS08225 (LZ581_08225) 1758219..1758446 - 228 WP_006809324.1 YccJ family protein -
LZ581_RS08230 (LZ581_08230) 1758465..1759061 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
LZ581_RS08235 (LZ581_08235) 1759452..1759622 + 171 WP_001273664.1 general stress protein -
LZ581_RS08240 (LZ581_08240) 1759739..1760644 + 906 WP_032653183.1 DMT family transporter -
LZ581_RS08245 (LZ581_08245) 1760718..1760987 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
LZ581_RS08250 (LZ581_08250) 1760994..1761515 + 522 WP_254309704.1 GNAT family N-acetyltransferase Toxin
LZ581_RS08255 (LZ581_08255) 1761574..1762896 - 1323 WP_032670921.1 pyrimidine utilization transport protein G -
LZ581_RS08260 (LZ581_08260) 1762918..1763409 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
LZ581_RS08265 (LZ581_08265) 1763422..1764012 - 591 WP_017693662.1 malonic semialdehyde reductase -
LZ581_RS08270 (LZ581_08270) 1764022..1764822 - 801 WP_023296287.1 pyrimidine utilization protein D -
LZ581_RS08275 (LZ581_08275) 1764830..1765216 - 387 WP_015570870.1 pyrimidine utilization protein C -
LZ581_RS08280 (LZ581_08280) 1765228..1765917 - 690 WP_058689480.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19368.14 Da        Isoelectric Point: 7.3996

>T250500 WP_254309704.1 NZ_CP100388:1760994-1761515 [Enterobacter hormaechei subsp. steigerwaltii]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNECGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT250500 WP_015570876.1 NZ_CP100388:1760718-1760987 [Enterobacter hormaechei subsp. steigerwaltii]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References