Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 663197..663850 Replicon chromosome
Accession NC_014920
Organism Haemophilus influenzae F3031

Toxin (Protein)


Gene name vapC Uniprot ID E7A495
Locus tag HIBPF_RS03355 Protein ID WP_013525780.1
Coordinates 663458..663850 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C2R5S0
Locus tag HIBPF_RS03350 Protein ID WP_006996057.1
Coordinates 663197..663457 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIBPF_RS03335 659047..660012 - 966 WP_013525778.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
HIBPF_RS03340 660009..661523 - 1515 WP_041174913.1 sodium/proline symporter PutP -
HIBPF_RS03345 661639..663114 + 1476 WP_006996058.1 ribonuclease G -
HIBPF_RS03350 663197..663457 + 261 WP_006996057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HIBPF_RS03355 663458..663850 + 393 WP_013525780.1 type II toxin-antitoxin system VapC family toxin Toxin
HIBPF_RS10030 664200..665608 + 1409 Protein_650 YadA-like family protein -
HIBPF_RS03365 665805..667472 + 1668 WP_013525782.1 glutamine--tRNA ligase -
HIBPF_RS03370 667550..667981 + 432 WP_013525783.1 YcgN family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14724.18 Da        Isoelectric Point: 4.6908

>T25050 WP_013525780.1 NC_014920:663458-663850 [Haemophilus influenzae F3031]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFELVPNLILENWCSV

Download         Length: 393 bp

>T25050 NC_014920:663458-663850 [Haemophilus influenzae F3031]
ATGTATATGTTAGATACGAATACTGTGAGTTATTTTTTCCGTAAAGTGCCTTCTGTAGTAGAACGATTAAGGCTGCTTAA
TCCTGAAATTCTCTGTATTTCTTCTGTTACCGCCGCTGAATTATTTTATGGTGTGGCAAAGCGTAATAATCTGCAACTTT
CACAGTTTCTAGATATATTTTTATCTGCGATTTCTATTTTAGAATGGGATACGAAAACCGCTGAAATTTATGGCAAGCTA
AGAGCTGAAATGGAAAAAGAAGGCAAAGTAATGGGCGTACAAGATCAGATGATTGCTGCTCACGCTTTAGCTAATGAATG
TGTTTTAGTCACGAGTGATAAAGCTTTTGAGCTTGTCCCCAACTTGATTTTAGAAAATTGGTGTAGTGTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10301.56 Da        Isoelectric Point: 4.9010

>AT25050 WP_006996057.1 NC_014920:663197-663457 [Haemophilus influenzae F3031]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Download         Length: 261 bp

>AT25050 NC_014920:663197-663457 [Haemophilus influenzae F3031]
ATGGAAAAAATCGCACGTTTATTTAGAAATGGTCGCAATCAAGCCGTTCGTTTACCTGTGGAATTTGAGTTTGACGCCAC
TCAAATTTATGTTTTCAAAGAAGAAAATGGCGATATTAGGCTTTCAACTCGTTCTCGTAGCCAGCAAAATTGGCAGAAAG
TCTTCGAATTGTTACCTACAATTCAATGTGATGAAGATTTTTTATCAGAAAAAGAGCGTAAGCAAGAAGTGGCAACGCGA
GATCCTTTTGAGGGCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2R1L6

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R5S0

References