Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3614427..3614980 Replicon chromosome
Accession NZ_CP100360
Organism Halomonas sp. 3H

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NFC98_RS16675 Protein ID WP_254276019.1
Coordinates 3614657..3614980 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NFC98_RS16670 Protein ID WP_254276018.1
Coordinates 3614427..3614660 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFC98_RS16640 3609991..3611052 + 1062 WP_254276012.1 C45 family peptidase -
NFC98_RS16645 3611136..3611507 + 372 WP_254276013.1 hypothetical protein -
NFC98_RS16650 3611584..3612171 - 588 WP_254276014.1 DUF4202 domain-containing protein -
NFC98_RS16655 3612294..3612614 + 321 WP_254276015.1 antibiotic biosynthesis monooxygenase -
NFC98_RS16660 3612747..3613145 - 399 WP_254276016.1 DUF4168 domain-containing protein -
NFC98_RS16665 3613302..3614108 - 807 WP_254276017.1 hypothetical protein -
NFC98_RS16670 3614427..3614660 + 234 WP_254276018.1 antitoxin MazE family protein Antitoxin
NFC98_RS16675 3614657..3614980 + 324 WP_254276019.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NFC98_RS16680 3615766..3616278 + 513 WP_254276020.1 WYL domain-containing protein -
NFC98_RS16685 3616265..3617491 - 1227 WP_254276021.1 YbfB/YjiJ family MFS transporter -
NFC98_RS16690 3617726..3618322 + 597 WP_254276022.1 class I SAM-dependent methyltransferase -
NFC98_RS16695 3618337..3619341 + 1005 WP_254276023.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11597.40 Da        Isoelectric Point: 8.9139

>T250496 WP_254276019.1 NZ_CP100360:3614657-3614980 [Halomonas sp. 3H]
MRRGDLVTIALSGDFGKPRPALIIQSDQFAGTGSVTVLLLSSTRVDAPLIRLDVESTPENGLQRRSQIMVDKPMTVKRER
VGEAFGHLDDSTMVAVNRALAVFLGFA

Download         Length: 324 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8436.35 Da        Isoelectric Point: 4.2659

>AT250496 WP_254276018.1 NZ_CP100360:3614427-3614660 [Halomonas sp. 3H]
MVATDNVNNRVKRHRAALRAAGLRPIQIWVPDTRQPGFAEEARRQCAAVAAADAGDQDLQDFMDAALLDLDDDECDA

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References