Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2889267..2889904 Replicon chromosome
Accession NZ_CP100351
Organism Desulfomicrobium sp. ZS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NLA06_RS12835 Protein ID WP_254078315.1
Coordinates 2889503..2889904 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NLA06_RS12830 Protein ID WP_254078314.1
Coordinates 2889267..2889500 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA06_RS12820 (NLA06_12820) 2885331..2886743 - 1413 WP_254078312.1 sugar transferase -
NLA06_RS12825 (NLA06_12825) 2886753..2888312 - 1560 WP_254078313.1 VPLPA-CTERM-specific exosortase XrtD -
NLA06_RS12830 (NLA06_12830) 2889267..2889500 + 234 WP_254078314.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NLA06_RS12835 (NLA06_12835) 2889503..2889904 + 402 WP_254078315.1 tRNA(fMet)-specific endonuclease VapC Toxin
NLA06_RS12840 (NLA06_12840) 2890019..2891161 - 1143 WP_254078316.1 AAA family ATPase -
NLA06_RS12845 (NLA06_12845) 2891244..2892122 - 879 WP_254078317.1 capsular biosynthesis protein -
NLA06_RS12850 (NLA06_12850) 2892238..2893965 - 1728 WP_254078318.1 Wzz/FepE/Etk N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14904.14 Da        Isoelectric Point: 6.8812

>T250493 WP_254078315.1 NZ_CP100351:2889503-2889904 [Desulfomicrobium sp. ZS1]
MLKYLLDTNIVIYVIKNRPLSVLKTFNQNHGRMAISSITLAELAHGVEKSADPARNLTVVEDFVSRLEVLPYDERAAWQY
GLIRAALERQGTPIGVNDLHIAGHARSLGLVIVTNNLREFERVPGVSVENWVE

Download         Length: 402 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8597.73 Da        Isoelectric Point: 5.0339

>AT250493 WP_254078314.1 NZ_CP100351:2889267-2889500 [Desulfomicrobium sp. ZS1]
METGTVFINNRTQAVRLPAGTRFPDSVKRVQVRVVGKERILTPVDAAWDSFFLGGLTVTDDFMAERAEQAQSEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References