250492

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/RHH(antitoxin)
Location 2880105..2880676 Replicon chromosome
Accession NZ_CP100351
Organism Desulfomicrobium sp. ZS1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NLA06_RS12795 Protein ID WP_254078308.1
Coordinates 2880386..2880676 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID C7LSA4
Locus tag NLA06_RS12790 Protein ID WP_015774741.1
Coordinates 2880105..2880398 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA06_RS12765 (NLA06_12765) 2875627..2876637 - 1011 WP_254078303.1 GDP-L-fucose synthase -
NLA06_RS12770 (NLA06_12770) 2876851..2877939 - 1089 WP_254078304.1 GDP-mannose 4,6-dehydratase -
NLA06_RS12775 (NLA06_12775) 2878411..2878779 - 369 WP_254078305.1 four helix bundle protein -
NLA06_RS12780 (NLA06_12780) 2879272..2879550 + 279 WP_254078306.1 type II toxin-antitoxin system RelE/ParE family toxin -
NLA06_RS12785 (NLA06_12785) 2879559..2879888 + 330 WP_254078307.1 HigA family addiction module antitoxin -
NLA06_RS12790 (NLA06_12790) 2880105..2880398 + 294 WP_015774741.1 CopG family transcriptional regulator Antitoxin
NLA06_RS12795 (NLA06_12795) 2880386..2880676 + 291 WP_254078308.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLA06_RS17475 2880945..2881391 - 447 WP_256479201.1 PilZ domain-containing protein -
NLA06_RS12805 (NLA06_12805) 2881570..2881728 - 159 WP_015774744.1 hypothetical protein -
NLA06_RS12810 (NLA06_12810) 2882014..2882568 - 555 WP_254078310.1 hypothetical protein -
NLA06_RS12815 (NLA06_12815) 2882948..2885314 - 2367 WP_254078311.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10643.25 Da        Isoelectric Point: 6.7089

>T250492 WP_254078308.1 NZ_CP100351:2880386-2880676 [Desulfomicrobium sp. ZS1]
MPRLIWTAGAVDGLGKIHRFLAEKDAQAAAKALDAIRKGANILRYFPQAGRPTEDLEPEHRELLIPFGASGYAVFYETID
DCICILTVKHQKEAGY

Download         Length: 291 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11173.87 Da        Isoelectric Point: 5.9026

>AT250492 WP_015774741.1 NZ_CP100351:2880105-2880398 [Desulfomicrobium sp. ZS1]
MPSQGPIKPTSIKLPLELHARVQHIAMVRKRSVHEVMIRAMETYVDREEKREAIRQECIKAHDEYMLTGLHVTGEEVDAW
IDQLVDGNETEMPACHV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB C7LSA4

References