Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1529331..1529920 Replicon chromosome
Accession NZ_CP100351
Organism Desulfomicrobium sp. ZS1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NLA06_RS06890 Protein ID WP_254080363.1
Coordinates 1529331..1529585 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NLA06_RS06895 Protein ID WP_254080364.1
Coordinates 1529582..1529920 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA06_RS06880 (NLA06_06880) 1525130..1526764 + 1635 WP_254080361.1 glutamate synthase-related protein -
NLA06_RS06885 (NLA06_06885) 1526777..1529161 + 2385 WP_254080362.1 FAD-dependent oxidoreductase -
NLA06_RS06890 (NLA06_06890) 1529331..1529585 + 255 WP_254080363.1 type II toxin-antitoxin system HicA family toxin Toxin
NLA06_RS06895 (NLA06_06895) 1529582..1529920 + 339 WP_254080364.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLA06_RS06900 (NLA06_06900) 1530040..1530291 - 252 WP_254080365.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
NLA06_RS06905 (NLA06_06905) 1530375..1531514 - 1140 WP_254080366.1 Fic family protein -
NLA06_RS06910 (NLA06_06910) 1531765..1533129 - 1365 WP_254080367.1 sigma 54-interacting transcriptional regulator -
NLA06_RS06915 (NLA06_06915) 1533379..1533606 + 228 WP_254080368.1 hypothetical protein -
NLA06_RS06920 (NLA06_06920) 1533644..1533865 + 222 WP_254080369.1 hypothetical protein -
NLA06_RS06925 (NLA06_06925) 1533885..1534889 + 1005 WP_254080370.1 bile acid:sodium symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(56-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9509.87 Da        Isoelectric Point: 10.0867

>T250490 WP_254080363.1 NZ_CP100351:1529331-1529585 [Desulfomicrobium sp. ZS1]
MKRKHESTLRRIFDHPTSGGIKWADIEALFAELGAEIAEREGSRISVFLFGEIRIFHRPHPSPDTDKGAVASIRKWLETN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12140.82 Da        Isoelectric Point: 5.2069

>AT250490 WP_254080364.1 NZ_CP100351:1529582-1529920 [Desulfomicrobium sp. ZS1]
MKNVLDFPGGYSAVIGYDSELEMFRGEFVGLNGGADFYATDLEGLKREGALSLKVFLDECTARGIEPKKAKGKFALRLDQ
DIYRQATIAAAASGKSLNQFITEAVREAVARA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References