Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 542262..542883 Replicon chromosome
Accession NZ_CP100351
Organism Desulfomicrobium sp. ZS1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NLA06_RS02400 Protein ID WP_254079537.1
Coordinates 542539..542883 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NLA06_RS02395 Protein ID WP_254079536.1
Coordinates 542262..542555 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA06_RS02385 (NLA06_02385) 537913..540234 + 2322 WP_254079534.1 diguanylate cyclase -
NLA06_RS02390 (NLA06_02390) 540206..541933 + 1728 WP_254079535.1 sensor domain-containing diguanylate cyclase -
NLA06_RS02395 (NLA06_02395) 542262..542555 - 294 WP_254079536.1 putative addiction module antidote protein Antitoxin
NLA06_RS02400 (NLA06_02400) 542539..542883 - 345 WP_254079537.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLA06_RS02405 (NLA06_02405) 543121..544224 + 1104 WP_254079538.1 ATP-dependent 6-phosphofructokinase -
NLA06_RS02410 (NLA06_02410) 544303..545586 - 1284 WP_254079539.1 4Fe-4S binding protein -
NLA06_RS02415 (NLA06_02415) 545762..546616 + 855 WP_256479893.1 TIGR02285 family protein -
NLA06_RS02420 (NLA06_02420) 546628..547593 - 966 WP_254079541.1 zinc metalloprotease HtpX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-102)

Antitoxin

(2-94)


Sequences


Toxin        


Download         Length: 115 a.a.        Molecular weight: 13368.25 Da        Isoelectric Point: 9.8503

>T250488 WP_254079537.1 NZ_CP100351:c542883-542539 [Desulfomicrobium sp. ZS1]
MYPNRYNLFISTFHQTDVFSCWLKNIKDIKTRARIVARIRSAEHGNLGDCTPVGEGVSEMRLHFGPGYRLYFWQEGGQVY
WLLAGGEKSTQKRDIERSKKLRYEIEEITHGKNK

Download         Length: 345 bp


Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10413.12 Da        Isoelectric Point: 5.1037

>AT250488 WP_254079536.1 NZ_CP100351:c542555-542262 [Desulfomicrobium sp. ZS1]
MVKISKFDAVDYLDSEEMMAEYLAAAVEDDNPDVFLAALADVAKARGMAQLAKDTGLGRESLYKTLAPGAKPRFETIMKI
TKALGVPLSPKAVIAHT

Download         Length: 294 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References