250482

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 971915..972416 Replicon chromosome
Accession NZ_CP100340
Organism Streptococcus suis strain STC78

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NKZ79_RS04945 Protein ID WP_024405694.1
Coordinates 971915..972181 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NKZ79_RS04950 Protein ID WP_024417206.1
Coordinates 972165..972416 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ79_RS04925 (NKZ79_04925) 967546..968616 + 1071 WP_014636926.1 tyrosine recombinase XerS -
NKZ79_RS04930 (NKZ79_04930) 968686..970194 - 1509 WP_172001163.1 phosphomannomutase/phosphoglucomutase -
NKZ79_RS04935 (NKZ79_04935) 970270..971211 - 942 WP_024417207.1 sensor histidine kinase -
NKZ79_RS04940 (NKZ79_04940) 971208..971873 - 666 WP_024405695.1 response regulator transcription factor -
NKZ79_RS04945 (NKZ79_04945) 971915..972181 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKZ79_RS04950 (NKZ79_04950) 972165..972416 - 252 WP_024417206.1 DUF6290 family protein Antitoxin
NKZ79_RS04955 (NKZ79_04955) 972508..974478 - 1971 WP_024417205.1 ABC transporter permease -
NKZ79_RS04960 (NKZ79_04960) 974479..975231 - 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
NKZ79_RS04965 (NKZ79_04965) 975252..975629 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NKZ79_RS04970 (NKZ79_04970) 975642..975782 - 141 WP_012775106.1 hypothetical protein -
NKZ79_RS04975 (NKZ79_04975) 975922..977088 - 1167 WP_024417204.1 ATP-grasp domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 909341..1060567 151226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T250482 WP_024405694.1 NZ_CP100340:c972181-971915 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9452.70 Da        Isoelectric Point: 3.7952

>AT250482 WP_024417206.1 NZ_CP100340:c972416-972165 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45


Antitoxin

Source ID Structure

References