25048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 585789..586324 Replicon chromosome
Accession NC_014920
Organism Haemophilus influenzae F3031

Toxin (Protein)


Gene name relE Uniprot ID E7A433
Locus tag HIBPF_RS03000 Protein ID WP_013525737.1
Coordinates 586061..586324 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A432
Locus tag HIBPF_RS02995 Protein ID WP_013525736.1
Coordinates 585789..586064 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIBPF_RS02975 581802..582938 + 1137 WP_013525733.1 DUF2827 family protein -
HIBPF_RS10360 582982..583077 - 96 Protein_573 IS3 family transposase -
HIBPF_RS02980 583104..583756 + 653 Protein_574 IS1595 family transposase -
HIBPF_RS02985 583842..584816 - 975 WP_006995878.1 zinc transporter permease subunit ZevB -
HIBPF_RS02990 584819..585439 - 621 WP_005694310.1 zinc transporter binding subunit ZevA -
HIBPF_RS02995 585789..586064 + 276 WP_013525736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HIBPF_RS03000 586061..586324 + 264 WP_013525737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HIBPF_RS03005 586419..588089 + 1671 WP_013525738.1 energy-dependent translational throttle protein EttA -
HIBPF_RS03010 588150..588491 + 342 WP_006995879.1 SirB2 family protein -
HIBPF_RS03015 588496..590466 + 1971 WP_013525739.1 tRNA(Met) cytidine acetyltransferase TmcA -
HIBPF_RS10485 590463..590636 + 174 WP_005652999.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 583104..583679 575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T25048 WP_013525737.1 NC_014920:586061-586324 [Haemophilus influenzae F3031]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T25048 NC_014920:586061-586324 [Haemophilus influenzae F3031]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.81 Da        Isoelectric Point: 6.0646

>AT25048 WP_013525736.1 NC_014920:585789-586064 [Haemophilus influenzae F3031]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT25048 NC_014920:585789-586064 [Haemophilus influenzae F3031]
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTACGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QSH1

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R2R7

References