250476

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 971943..972444 Replicon chromosome
Accession NZ_CP100338
Organism Streptococcus suis strain STC80

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NKZ64_RS04945 Protein ID WP_024405694.1
Coordinates 971943..972209 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NKZ64_RS04950 Protein ID WP_024417206.1
Coordinates 972193..972444 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ64_RS04925 (NKZ64_04925) 967574..968644 + 1071 WP_014636926.1 tyrosine recombinase XerS -
NKZ64_RS04930 (NKZ64_04930) 968714..970222 - 1509 WP_172001163.1 phosphomannomutase/phosphoglucomutase -
NKZ64_RS04935 (NKZ64_04935) 970298..971239 - 942 WP_024417207.1 sensor histidine kinase -
NKZ64_RS04940 (NKZ64_04940) 971236..971901 - 666 WP_024405695.1 response regulator transcription factor -
NKZ64_RS04945 (NKZ64_04945) 971943..972209 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKZ64_RS04950 (NKZ64_04950) 972193..972444 - 252 WP_024417206.1 DUF6290 family protein Antitoxin
NKZ64_RS04955 (NKZ64_04955) 972536..974506 - 1971 WP_024417205.1 ABC transporter permease -
NKZ64_RS04960 (NKZ64_04960) 974507..975259 - 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
NKZ64_RS04965 (NKZ64_04965) 975280..975657 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NKZ64_RS04970 (NKZ64_04970) 975670..975810 - 141 WP_012775106.1 hypothetical protein -
NKZ64_RS04975 (NKZ64_04975) 975950..977116 - 1167 WP_024417204.1 ATP-grasp domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 909369..1060609 151240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T250476 WP_024405694.1 NZ_CP100338:c972209-971943 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9452.70 Da        Isoelectric Point: 3.7952

>AT250476 WP_024417206.1 NZ_CP100338:c972444-972193 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45


Antitoxin

Source ID Structure

References