Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1320785..1322217 Replicon chromosome
Accession NZ_CP100336
Organism Streptococcus suis strain STC81

Toxin (Protein)


Gene name abiEi Uniprot ID G7SFZ4
Locus tag NKZ66_RS06590 Protein ID WP_001030299.1
Coordinates 1321372..1322217 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID G7SFZ3
Locus tag NKZ66_RS06585 Protein ID WP_000037237.1
Coordinates 1320785..1321375 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ66_RS06585 (NKZ66_06585) 1320785..1321375 + 591 WP_000037237.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
NKZ66_RS06590 (NKZ66_06590) 1321372..1322217 + 846 WP_001030299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NKZ66_RS06595 (NKZ66_06595) 1322280..1325081 - 2802 WP_000656693.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32462.14 Da        Isoelectric Point: 5.4404

>T250472 WP_001030299.1 NZ_CP100336:1321372-1322217 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23056.59 Da        Isoelectric Point: 7.8056

>AT250472 WP_000037237.1 NZ_CP100336:1320785-1321375 [Streptococcus suis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPLGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SFZ4

Antitoxin

Source ID Structure
AlphaFold DB G7SFZ3

References