Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 1284656..1285899 Replicon chromosome
Accession NZ_CP100336
Organism Streptococcus suis strain STC81

Toxin (Protein)


Gene name sezT Uniprot ID G7SEB4
Locus tag NKZ66_RS06405 Protein ID WP_001235242.1
Coordinates 1284656..1285423 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag NKZ66_RS06410 Protein ID WP_000578719.1
Coordinates 1285423..1285899 (-) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ66_RS06390 (NKZ66_06390) 1281044..1281409 - 366 WP_000431640.1 MobC family plasmid mobilization relaxosome protein -
NKZ66_RS06395 (NKZ66_06395) 1281412..1281774 - 363 WP_000140674.1 SAG1252 family conjugative relaxosome accessory protein -
NKZ66_RS06400 (NKZ66_06400) 1282112..1284655 - 2544 WP_000601012.1 AAA family ATPase -
NKZ66_RS06405 (NKZ66_06405) 1284656..1285423 - 768 WP_001235242.1 type II toxin-antitoxin system toxin PezT Toxin
NKZ66_RS06410 (NKZ66_06410) 1285423..1285899 - 477 WP_000578719.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
NKZ66_RS06415 (NKZ66_06415) 1285969..1286259 - 291 WP_000667951.1 hypothetical protein -
NKZ66_RS06420 (NKZ66_06420) 1286310..1286699 - 390 WP_000048066.1 DUF5945 family protein -
NKZ66_RS06425 (NKZ66_06425) 1286696..1286923 - 228 WP_000110922.1 DUF5965 family protein -
NKZ66_RS06430 (NKZ66_06430) 1286951..1288051 - 1101 WP_000196860.1 toprim domain-containing protein -
NKZ66_RS06435 (NKZ66_06435) 1288115..1289758 - 1644 WP_004607528.1 recombinase family protein -
NKZ66_RS06440 (NKZ66_06440) 1289849..1290745 + 897 WP_001809760.1 ParA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island erm(B) / tet(O) - 1269589..1301689 32100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(28-214)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 256 a.a.        Molecular weight: 28985.80 Da        Isoelectric Point: 5.1126

>T250471 WP_001235242.1 NZ_CP100336:c1285423-1284656 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Download         Length: 768 bp


Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18266.77 Da        Isoelectric Point: 4.6424

>AT250471 WP_000578719.1 NZ_CP100336:c1285899-1285423 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G7SEB4


Antitoxin

Source ID Structure

References