Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 109623..110273 Replicon chromosome
Accession NC_014920
Organism Haemophilus influenzae F3031

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QXL9
Locus tag HIBPF_RS00560 Protein ID WP_041174880.1
Coordinates 110094..110273 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A7Z3
Locus tag HIBPF_RS00555 Protein ID WP_013525461.1
Coordinates 109623..110030 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIBPF_RS00540 105331..106218 - 888 WP_013525457.1 GPO family capsid scaffolding protein -
HIBPF_RS00545 106422..108226 + 1805 Protein_104 terminase ATPase subunit family protein -
HIBPF_RS00550 108216..109250 + 1035 WP_013525459.1 phage portal protein -
HIBPF_RS09985 109332..109592 + 261 WP_013525460.1 ogr/Delta-like zinc finger family protein -
HIBPF_RS00555 109623..110030 - 408 WP_013525461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HIBPF_RS00560 110094..110273 - 180 WP_041174880.1 type II toxin-antitoxin system HicA family toxin Toxin
HIBPF_RS00565 110353..110871 - 519 WP_013525462.1 phage N-6-adenine-methyltransferase -
HIBPF_RS00570 110881..111186 - 306 WP_013525463.1 hypothetical protein -
HIBPF_RS00575 111198..113537 - 2340 WP_013525464.1 replication endonuclease -
HIBPF_RS00580 113598..113933 - 336 WP_013525465.1 hypothetical protein -
HIBPF_RS00585 113952..114455 - 504 WP_013525466.1 hypothetical protein -
HIBPF_RS00590 114588..114827 - 240 WP_041174881.1 hypothetical protein -
HIBPF_RS00595 114824..115015 - 192 WP_041174882.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 86542..117875 31333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6686.87 Da        Isoelectric Point: 10.8241

>T25047 WP_041174880.1 NC_014920:c110273-110094 [Haemophilus influenzae F3031]
MNSAKIIKQIEDDGWYLVNVVGSHHQFKHPTKKGRVTVPHPKKDLQIKTVKSILKQAGI

Download         Length: 180 bp

>T25047 NC_014920:c110273-110094 [Haemophilus influenzae F3031]
ATGAATAGTGCAAAAATAATTAAACAAATTGAGGATGACGGTTGGTATCTTGTAAATGTTGTCGGTAGTCACCATCAATT
CAAGCATCCAACAAAGAAAGGGCGAGTTACTGTTCCACATCCGAAAAAGGATTTACAAATAAAGACGGTAAAATCAATAT
TAAAGCAAGCGGGGATTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14978.99 Da        Isoelectric Point: 4.3488

>AT25047 WP_013525461.1 NC_014920:c110030-109623 [Haemophilus influenzae F3031]
MLYPIGIEMGDENHTYGVVVPDVPGCFSAGDTLEEAFINAKEAITFHIEGLLEDGEEIPQPTSLQEHVKNPEYEGFTFSF
VDVDLTHLMGKAEKINVTLPSLLIKRIDSFVATHPEYKNRSNFLAQVVTNKLLAA

Download         Length: 408 bp

>AT25047 NC_014920:c110030-109623 [Haemophilus influenzae F3031]
ATGTTATACCCAATCGGAATAGAAATGGGCGATGAAAATCACACATACGGTGTGGTGGTGCCTGATGTGCCAGGTTGTTT
TTCAGCAGGTGATACATTAGAAGAGGCATTCATCAACGCAAAAGAGGCGATTACCTTCCATATTGAAGGCCTGTTAGAAG
ATGGTGAGGAAATTCCGCAGCCAACATCATTACAAGAGCACGTTAAAAACCCAGAGTATGAAGGCTTTACATTTAGTTTT
GTGGATGTAGATTTAACCCATCTAATGGGGAAAGCCGAAAAAATCAATGTAACCTTGCCTAGTCTTTTAATTAAACGCAT
TGATAGTTTTGTAGCAACGCATCCTGAATATAAAAACAGAAGCAACTTTTTGGCGCAGGTGGTCACAAATAAGTTACTCG
CAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QXL9

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYR1

References