250458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 971904..972405 Replicon chromosome
Accession NZ_CP100332
Organism Streptococcus suis strain STC84

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NKZ65_RS04945 Protein ID WP_024405694.1
Coordinates 971904..972170 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NKZ65_RS04950 Protein ID WP_024417206.1
Coordinates 972154..972405 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ65_RS04925 (NKZ65_04925) 967535..968605 + 1071 WP_014636926.1 tyrosine recombinase XerS -
NKZ65_RS04930 (NKZ65_04930) 968675..970183 - 1509 WP_172001163.1 phosphomannomutase/phosphoglucomutase -
NKZ65_RS04935 (NKZ65_04935) 970259..971200 - 942 WP_024417207.1 sensor histidine kinase -
NKZ65_RS04940 (NKZ65_04940) 971197..971862 - 666 WP_024405695.1 response regulator transcription factor -
NKZ65_RS04945 (NKZ65_04945) 971904..972170 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKZ65_RS04950 (NKZ65_04950) 972154..972405 - 252 WP_024417206.1 DUF6290 family protein Antitoxin
NKZ65_RS04955 (NKZ65_04955) 972497..974467 - 1971 WP_024417205.1 ABC transporter permease -
NKZ65_RS04960 (NKZ65_04960) 974468..975220 - 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
NKZ65_RS04965 (NKZ65_04965) 975241..975618 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NKZ65_RS04970 (NKZ65_04970) 975631..975771 - 141 WP_012775106.1 hypothetical protein -
NKZ65_RS04975 (NKZ65_04975) 975911..977077 - 1167 WP_024417204.1 ATP-grasp domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 909332..1060556 151224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T250458 WP_024405694.1 NZ_CP100332:c972170-971904 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9452.70 Da        Isoelectric Point: 3.7952

>AT250458 WP_024417206.1 NZ_CP100332:c972405-972154 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45


Antitoxin

Source ID Structure

References