Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 565178..565661 Replicon chromosome
Accession NZ_CP100332
Organism Streptococcus suis strain STC84

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag NKZ65_RS02935 Protein ID WP_009910443.1
Coordinates 565401..565661 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag NKZ65_RS02930 Protein ID WP_012775256.1
Coordinates 565178..565399 (+) Length 74 a.a.

Genomic Context

NKZ65_RS02900NKZ65_RS02910NKZ65_RS02915NKZ65_RS02925NKZ65_RS02930NKZ65_RS02935NKZ65_RS02940NKZ65_RS02955NKZ65_RS02960NKZ65_RS02905NKZ65_RS02920NKZ65_RS02945NKZ65_RS02950
Location: 560185..560820 (636 bp)
Type: Others
Protein ID: WP_024386271.1
Location: 561604..562731 (1128 bp)
Type: Others
Protein ID: WP_002935718.1
Location: 562722..562949 (228 bp)
Type: Others
Protein ID: WP_002935708.1
Location: 563561..564868 (1308 bp)
Type: Others
Protein ID: WP_002935704.1
Location: 565178..565399 (222 bp)
Type: Antitoxin
Protein ID: WP_012775256.1
Location: 565401..565661 (261 bp)
Type: Toxin
Protein ID: WP_009910443.1
Location: 565828..566469 (642 bp)
Type: Others
Protein ID: WP_024413325.1
Location: 567891..569057 (1167 bp)
Type: Others
Protein ID: WP_204101610.1
Location: 569047..570276 (1230 bp)
Type: Others
Protein ID: WP_024417660.1
Location: 560851..561496 (646 bp)
Type: Others
Protein ID: Protein_522
Location: 562959..563411 (453 bp)
Type: Others
Protein ID: WP_013730449.1
Location: 566502..566687 (186 bp)
Type: Others
Protein ID: WP_002935693.1
Location: 566751..567755 (1005 bp)
Type: Others
Protein ID: WP_024402853.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NKZ65_RS02900 (NKZ65_02900)560185..560820+636WP_024386271.1phosphoserine phosphatase SerB-
NKZ65_RS02905 (NKZ65_02905)560851..561496-646Protein_522HAD family hydrolase-
NKZ65_RS02910 (NKZ65_02910)561604..562731+1128WP_002935718.1glycerate kinase-
NKZ65_RS02915 (NKZ65_02915)562722..562949+228WP_002935708.1hypothetical protein-
NKZ65_RS02920 (NKZ65_02920)562959..563411-453WP_013730449.1DUF1694 domain-containing protein-
NKZ65_RS02925 (NKZ65_02925)563561..564868+1308WP_002935704.1phosphopyruvate hydratase-
NKZ65_RS02930 (NKZ65_02930)565178..565399+222WP_012775256.1DUF6290 family proteinAntitoxin
NKZ65_RS02935 (NKZ65_02935)565401..565661+261WP_009910443.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NKZ65_RS02940 (NKZ65_02940)565828..566469+642WP_024413325.1HAD family hydrolase-
NKZ65_RS02945 (NKZ65_02945)566502..566687-186WP_002935693.1hypothetical protein-
NKZ65_RS02950 (NKZ65_02950)566751..567755-1005WP_024402853.1lactonase family protein-
NKZ65_RS02955 (NKZ65_02955)567891..569057+1167WP_204101610.1AI-2E family transporter-
NKZ65_RS02960 (NKZ65_02960)569047..570276+1230WP_024417660.1tetratricopeptide repeat protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T250457 WP_009910443.1 NZ_CP100332:565401-565661 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT250457 WP_012775256.1 NZ_CP100332:565178-565399 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Z8BIZ7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0Z8BIX7

References