Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 1284715..1285958 Replicon chromosome
Accession NZ_CP100328
Organism Streptococcus suis strain STC86

Toxin (Protein)


Gene name sezT Uniprot ID G7SEB4
Locus tag NKZ81_RS06405 Protein ID WP_001235242.1
Coordinates 1284715..1285482 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag NKZ81_RS06410 Protein ID WP_000578719.1
Coordinates 1285482..1285958 (-) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ81_RS06390 (NKZ81_06390) 1281103..1281468 - 366 WP_000431640.1 MobC family plasmid mobilization relaxosome protein -
NKZ81_RS06395 (NKZ81_06395) 1281471..1281833 - 363 WP_000140674.1 SAG1252 family conjugative relaxosome accessory protein -
NKZ81_RS06400 (NKZ81_06400) 1282171..1284714 - 2544 WP_000601012.1 AAA family ATPase -
NKZ81_RS06405 (NKZ81_06405) 1284715..1285482 - 768 WP_001235242.1 type II toxin-antitoxin system toxin PezT Toxin
NKZ81_RS06410 (NKZ81_06410) 1285482..1285958 - 477 WP_000578719.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
NKZ81_RS06415 (NKZ81_06415) 1286028..1286318 - 291 WP_000667951.1 hypothetical protein -
NKZ81_RS06420 (NKZ81_06420) 1286369..1286758 - 390 WP_000048066.1 DUF5945 family protein -
NKZ81_RS06425 (NKZ81_06425) 1286755..1286982 - 228 WP_000110922.1 DUF5965 family protein -
NKZ81_RS06430 (NKZ81_06430) 1287010..1288110 - 1101 WP_000196860.1 toprim domain-containing protein -
NKZ81_RS06435 (NKZ81_06435) 1288174..1289817 - 1644 WP_004607528.1 recombinase family protein -
NKZ81_RS06440 (NKZ81_06440) 1289908..1290804 + 897 WP_001809760.1 ParA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island erm(B) / tet(O) - 1269648..1301748 32100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(28-214)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 256 a.a.        Molecular weight: 28985.80 Da        Isoelectric Point: 5.1126

>T250447 WP_001235242.1 NZ_CP100328:c1285482-1284715 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Download         Length: 768 bp


Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18266.77 Da        Isoelectric Point: 4.6424

>AT250447 WP_000578719.1 NZ_CP100328:c1285958-1285482 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G7SEB4


Antitoxin

Source ID Structure

References