250446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 969631..970132 Replicon chromosome
Accession NZ_CP100328
Organism Streptococcus suis strain STC86

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NKZ81_RS04935 Protein ID WP_024405694.1
Coordinates 969631..969897 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NKZ81_RS04940 Protein ID WP_024417206.1
Coordinates 969881..970132 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ81_RS04915 (NKZ81_04915) 965262..966332 + 1071 WP_014636926.1 tyrosine recombinase XerS -
NKZ81_RS04920 (NKZ81_04920) 966402..967910 - 1509 WP_172001163.1 phosphomannomutase/phosphoglucomutase -
NKZ81_RS04925 (NKZ81_04925) 967986..968927 - 942 WP_024417207.1 sensor histidine kinase -
NKZ81_RS04930 (NKZ81_04930) 968924..969589 - 666 WP_024405695.1 response regulator transcription factor -
NKZ81_RS04935 (NKZ81_04935) 969631..969897 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKZ81_RS04940 (NKZ81_04940) 969881..970132 - 252 WP_024417206.1 DUF6290 family protein Antitoxin
NKZ81_RS04945 (NKZ81_04945) 970224..972194 - 1971 WP_024417205.1 ABC transporter permease -
NKZ81_RS04950 (NKZ81_04950) 972195..972947 - 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
NKZ81_RS04955 (NKZ81_04955) 972968..973345 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NKZ81_RS04960 (NKZ81_04960) 973358..973498 - 141 WP_012775106.1 hypothetical protein -
NKZ81_RS04965 (NKZ81_04965) 973638..974804 - 1167 WP_024417204.1 ATP-grasp domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 907057..1058283 151226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T250446 WP_024405694.1 NZ_CP100328:c969897-969631 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9452.70 Da        Isoelectric Point: 3.7952

>AT250446 WP_024417206.1 NZ_CP100328:c970132-969881 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45


Antitoxin

Source ID Structure

References