Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 236212..236848 Replicon chromosome
Accession NC_014915
Organism Geobacillus sp. Y412MC52

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GYMC52_RS01275 Protein ID WP_003253417.1
Coordinates 236498..236848 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0D8C733
Locus tag GYMC52_RS01270 Protein ID WP_013144044.1
Coordinates 236212..236493 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYMC52_RS01250 232469..233086 - 618 WP_013522799.1 rhomboid family intramembrane serine protease -
GYMC52_RS01255 233200..233589 + 390 WP_011229738.1 holo-ACP synthase -
GYMC52_RS01260 233669..234682 + 1014 WP_013522800.1 outer membrane lipoprotein carrier protein LolA -
GYMC52_RS01265 234931..236085 + 1155 WP_013522801.1 alanine racemase -
GYMC52_RS01270 236212..236493 + 282 WP_013144044.1 hypothetical protein Antitoxin
GYMC52_RS01275 236498..236848 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GYMC52_RS01280 237114..239279 + 2166 WP_013522802.1 RNA-binding transcriptional accessory protein -
GYMC52_RS19115 239298..239411 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
GYMC52_RS01285 239501..239950 + 450 WP_013144047.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T25044 WP_003253417.1 NC_014915:236498-236848 [Geobacillus sp. Y412MC52]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T25044 NC_014915:236498-236848 [Geobacillus sp. Y412MC52]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGACTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10669.17 Da        Isoelectric Point: 7.2027

>AT25044 WP_013144044.1 NC_014915:236212-236493 [Geobacillus sp. Y412MC52]
VSESGATTEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT25044 NC_014915:236212-236493 [Geobacillus sp. Y412MC52]
GTGTCGGAATCTGGCGCAACAACGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8C733

References