Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4864613..4866294 Replicon chromosome
Accession NZ_CP100312
Organism Klebsiella pneumoniae strain 1020

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NKX97_RS23780 Protein ID WP_002885155.1
Coordinates 4864613..4865530 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag NKX97_RS23785 Protein ID WP_004192584.1
Coordinates 4865536..4866294 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKX97_RS23760 (4859919) 4859919..4861439 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NKX97_RS23765 (4861436) 4861436..4862434 + 999 WP_002885172.1 ribose ABC transporter permease -
NKX97_RS23770 (4862465) 4862465..4863406 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NKX97_RS23775 (4863481) 4863481..4864488 + 1008 WP_004177805.1 carbohydrate kinase family protein -
NKX97_RS23780 (4864613) 4864613..4865530 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NKX97_RS23785 (4865536) 4865536..4866294 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NKX97_RS23790 (4866380) 4866380..4867108 - 729 WP_002885152.1 response regulator transcription factor -
NKX97_RS23795 (4867381) 4867381..4869528 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NKX97_RS23800 (4869758) 4869758..4870444 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T250435 WP_002885155.1 NZ_CP100312:c4865530-4864613 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT250435 WP_004192584.1 NZ_CP100312:c4866294-4865536 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References