Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4697696..4698212 Replicon chromosome
Accession NZ_CP100312
Organism Klebsiella pneumoniae strain 1020

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag NKX97_RS22945 Protein ID WP_004192395.1
Coordinates 4697696..4697980 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag NKX97_RS22950 Protein ID WP_004192397.1
Coordinates 4697970..4698212 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKX97_RS22920 (4693113) 4693113..4693376 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NKX97_RS22925 (4693506) 4693506..4693679 + 174 WP_002886906.1 hypothetical protein -
NKX97_RS22930 (4693682) 4693682..4694425 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NKX97_RS22935 (4694782) 4694782..4696920 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NKX97_RS22940 (4697228) 4697228..4697692 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NKX97_RS22945 (4697696) 4697696..4697980 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKX97_RS22950 (4697970) 4697970..4698212 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NKX97_RS22955 (4698290) 4698290..4700200 - 1911 WP_004152270.1 PRD domain-containing protein -
NKX97_RS22960 (4700223) 4700223..4701377 - 1155 WP_004178372.1 lactonase family protein -
NKX97_RS22965 (4701444) 4701444..4702184 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T250434 WP_004192395.1 NZ_CP100312:c4697980-4697696 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT250434 WP_004192397.1 NZ_CP100312:c4698212-4697970 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References