Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yeeU/CbtA-CbeA |
| Location | 4612348..4613074 | Replicon | chromosome |
| Accession | NZ_CP100312 | ||
| Organism | Klebsiella pneumoniae strain 1020 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | NKX97_RS22580 | Protein ID | WP_107357767.1 |
| Coordinates | 4612348..4612689 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | NKX97_RS22585 | Protein ID | WP_107357768.1 |
| Coordinates | 4612724..4613074 (-) | Length | 117 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NKX97_RS22550 (4607366) | 4607366..4607632 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| NKX97_RS22555 (4607632) | 4607632..4608304 | + | 673 | Protein_4420 | DUF4400 domain-containing protein | - |
| NKX97_RS22560 (4608315) | 4608315..4609199 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| NKX97_RS22565 (4609398) | 4609398..4609586 | - | 189 | Protein_4422 | transposase | - |
| NKX97_RS22570 (4609603) | 4609603..4610714 | - | 1112 | Protein_4423 | IS3 family transposase | - |
| NKX97_RS22575 (4611082) | 4611082..4612089 | - | 1008 | WP_107357766.1 | restriction endonuclease | - |
| NKX97_RS22580 (4612348) | 4612348..4612689 | - | 342 | WP_107357767.1 | TA system toxin CbtA family protein | Toxin |
| NKX97_RS22585 (4612724) | 4612724..4613074 | - | 351 | WP_107357768.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NKX97_RS22590 (4613095) | 4613095..4613316 | - | 222 | WP_107357769.1 | DUF987 domain-containing protein | - |
| NKX97_RS22595 (4613332) | 4613332..4613805 | - | 474 | WP_107357770.1 | DNA repair protein RadC | - |
| NKX97_RS22600 (4613876) | 4613876..4614697 | - | 822 | WP_032437350.1 | DUF932 domain-containing protein | - |
| NKX97_RS22605 (4614793) | 4614793..4615470 | - | 678 | WP_107357771.1 | hypothetical protein | - |
| NKX97_RS22610 (4615755) | 4615755..4616648 | - | 894 | WP_107357772.1 | 50S ribosome-binding GTPase | - |
| NKX97_RS22615 (4616747) | 4616747..4617844 | - | 1098 | WP_117031494.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4601477..4641063 | 39586 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12929.02 Da Isoelectric Point: 10.0932
>T250433 WP_107357767.1 NZ_CP100312:c4612689-4612348 [Klebsiella pneumoniae]
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLLEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLLEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
Antitoxin
Download Length: 117 a.a. Molecular weight: 12974.90 Da Isoelectric Point: 6.6206
>AT250433 WP_107357768.1 NZ_CP100312:c4613074-4612724 [Klebsiella pneumoniae]
MSNKTLTVNDDTAEPWWGLSRNVIPCFGARLVQEGNRLHYLAGRASLTGQIHEADLLHLDQAFPVLLKQMELMLTCGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
MSNKTLTVNDDTAEPWWGLSRNVIPCFGARLVQEGNRLHYLAGRASLTGQIHEADLLHLDQAFPVLLKQMELMLTCGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
Download Length: 351 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|