Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842023..842680 Replicon chromosome
Accession NZ_CP100312
Organism Klebsiella pneumoniae strain 1020

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NKX97_RS04245 Protein ID WP_002916310.1
Coordinates 842270..842680 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NKX97_RS04240 Protein ID WP_002916312.1
Coordinates 842023..842289 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKX97_RS04215 (837179) 837179..838612 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NKX97_RS04220 (838731) 838731..839459 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NKX97_RS04225 (839509) 839509..839820 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NKX97_RS04230 (839984) 839984..840643 + 660 WP_002916317.1 hemolysin III family protein -
NKX97_RS04235 (840794) 840794..841777 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NKX97_RS04240 (842023) 842023..842289 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NKX97_RS04245 (842270) 842270..842680 + 411 WP_002916310.1 protein YgfX Toxin
NKX97_RS04250 (842687) 842687..843208 - 522 WP_002916308.1 flavodoxin FldB -
NKX97_RS04255 (843309) 843309..844205 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NKX97_RS04260 (844228) 844228..844941 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NKX97_RS04265 (844947) 844947..846680 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250425 WP_002916310.1 NZ_CP100312:842270-842680 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250425 WP_002916312.1 NZ_CP100312:842023-842289 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References