Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 4219175..4220091 Replicon chromosome
Accession NC_014910
Organism Alicycliphilus denitrificans BC

Toxin (Protein)


Gene name slvT Uniprot ID F4G8H2
Locus tag ALIDE_RS20120 Protein ID WP_013520794.1
Coordinates 4219175..4219723 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A858ZYW7
Locus tag ALIDE_RS20125 Protein ID WP_013520795.1
Coordinates 4219720..4220091 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALIDE_RS23635 4214765..4214923 - 159 Protein_4030 TetR family transcriptional regulator -
ALIDE_RS20100 4215033..4216559 + 1527 WP_013516260.1 IS21 family transposase -
ALIDE_RS20105 4216549..4217352 + 804 WP_013516261.1 IS21-like element ISThsp10 family helper ATPase IstB -
ALIDE_RS24640 4217362..4217520 - 159 WP_193352856.1 transposase -
ALIDE_RS23645 4217734..4218048 + 315 WP_081462206.1 hypothetical protein -
ALIDE_RS20115 4218240..4219187 - 948 WP_013520793.1 hypothetical protein -
ALIDE_RS20120 4219175..4219723 - 549 WP_013520794.1 RES family NAD+ phosphorylase Toxin
ALIDE_RS20125 4219720..4220091 - 372 WP_013520795.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
ALIDE_RS20130 4220406..4220735 - 330 WP_013520796.1 chorismate mutase -
ALIDE_RS20135 4220732..4222231 - 1500 WP_013520797.1 anthranilate synthase component I -
ALIDE_RS20140 4222574..4224334 + 1761 WP_013520798.1 MCP four helix bundle domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4147817..4232926 85109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(15-168)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20105.95 Da        Isoelectric Point: 4.7789

>T25042 WP_013520794.1 NC_014910:c4219723-4219175 [Alicycliphilus denitrificans BC]
MIPVAILGEGKAEAFYRIISPAYAGMPLSGMGAARQGGRFNRPGQEALYLAMDEATALAEYKQDNPWLRPGTICTFFVKG
LRVADFSAGFDPQKWPPLWADFAVDWRAEWFGKSVEPPTWYMSEDVIAEGLDGILFPSQARPDGINLVVYRSSARPADQL
RVYDPDGVLPKIAPFAGHPWTP

Download         Length: 549 bp

>T25042 NC_014910:c4219723-4219175 [Alicycliphilus denitrificans BC]
ATGATTCCAGTCGCGATCCTCGGCGAGGGCAAGGCCGAGGCTTTCTACCGCATCATCTCACCCGCTTATGCTGGCATGCC
GCTGTCCGGTATGGGGGCTGCGCGCCAGGGCGGTCGCTTCAATCGGCCCGGCCAGGAAGCCCTCTATCTGGCGATGGATG
AAGCCACTGCATTGGCGGAATACAAGCAGGACAACCCGTGGCTGCGTCCGGGCACGATCTGTACGTTCTTTGTCAAAGGG
CTGCGGGTGGCGGACTTCAGTGCGGGCTTCGATCCACAGAAGTGGCCGCCATTGTGGGCTGATTTCGCGGTGGACTGGCG
AGCGGAGTGGTTCGGTAAATCGGTTGAACCGCCGACTTGGTATATGTCCGAGGATGTGATTGCTGAGGGACTTGATGGAA
TCCTGTTCCCCTCGCAGGCACGGCCTGACGGCATCAATCTGGTGGTCTACCGGAGTTCTGCAAGGCCCGCGGACCAGTTG
CGCGTGTACGACCCCGATGGCGTTCTGCCGAAGATCGCTCCCTTCGCTGGTCACCCATGGACACCCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13512.43 Da        Isoelectric Point: 5.7134

>AT25042 WP_013520795.1 NC_014910:c4220091-4219720 [Alicycliphilus denitrificans BC]
MSAVLQQPFVEQFREPGTPYLSPVLLGDFLGFQVQELAERAHVHRNTPTARPQAPQLQKYLQDMVRVLAVATEMTGDEKR
AAFLVRNEPLRAFGYKTADALVQEGRVDAVIAYLESLAGGAAG

Download         Length: 372 bp

>AT25042 NC_014910:c4220091-4219720 [Alicycliphilus denitrificans BC]
ATGAGCGCCGTGCTGCAACAGCCTTTTGTCGAGCAATTCCGCGAGCCGGGTACGCCGTATCTGTCCCCGGTCCTGCTCGG
GGATTTCCTCGGCTTCCAGGTACAGGAGTTGGCCGAGCGCGCCCATGTGCATCGCAACACCCCGACCGCCAGGCCCCAGG
CGCCACAACTGCAAAAGTACCTTCAGGACATGGTGCGGGTACTTGCTGTGGCTACCGAGATGACCGGCGACGAAAAGCGC
GCTGCCTTCCTGGTGCGCAACGAACCGCTGCGCGCCTTCGGCTACAAGACCGCCGATGCCTTGGTTCAGGAGGGGCGGGT
CGACGCGGTCATTGCCTATCTGGAGTCGCTTGCAGGCGGTGCTGCTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F4G8H2

Antitoxin

Source ID Structure
AlphaFold DB A0A858ZYW7

References