Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4698889..4699405 Replicon chromosome
Accession NZ_CP100308
Organism Klebsiella pneumoniae strain 1021

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag NKY02_RS22955 Protein ID WP_004192395.1
Coordinates 4698889..4699173 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag NKY02_RS22960 Protein ID WP_004192397.1
Coordinates 4699163..4699405 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKY02_RS22930 (4694306) 4694306..4694569 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NKY02_RS22935 (4694699) 4694699..4694872 + 174 WP_002886906.1 hypothetical protein -
NKY02_RS22940 (4694875) 4694875..4695618 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NKY02_RS22945 (4695975) 4695975..4698113 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NKY02_RS22950 (4698421) 4698421..4698885 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NKY02_RS22955 (4698889) 4698889..4699173 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKY02_RS22960 (4699163) 4699163..4699405 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NKY02_RS22965 (4699483) 4699483..4701393 - 1911 WP_004152270.1 PRD domain-containing protein -
NKY02_RS22970 (4701416) 4701416..4702570 - 1155 WP_004178372.1 lactonase family protein -
NKY02_RS22975 (4702637) 4702637..4703377 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T250417 WP_004192395.1 NZ_CP100308:c4699173-4698889 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT250417 WP_004192397.1 NZ_CP100308:c4699405-4699163 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References